Plasma lipidomics profiling to identify signatures of pediatric medulloblastoma.

IF 2.5 3区医学 Q2 ONCOLOGY

Clinical & Translational Oncology Pub Date : 2025-08-20 DOI:10.1007/s12094-025-04008-7

Zhengyuan Shi, Chunjing Yang, Xiqiao Xu, Wanshui Wu, Li Bao

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引用次数: 0

Abstract

Background: Medulloblastoma is similar to other common tumors in the posterior cranial fossa of children in terms of the onset and clinical manifestations. Still, its main treatment methods, surgical methods and prognosis are quite different. Therefore, there is an urgent need for finding biomarkers for differential diagnosis.

Purpose: The purpose of this study was to identify new lipids and differential metabolic pathways by analyzing the significantly different lipids present in the plasma of children with medulloblastoma in comparison to those with other intracranial tumors.

Methods: In this study, 35 patients with medulloblastoma and 32 matched controls were enrolled. Plasma samples and medical records were collected, and untargeted lipidomics analyses were performed using UHPLC-MS/MS.

Results: A total of 97 differential lipids in the plasma of children with medulloblastoma were identified. Seven differential lipids could be potentially useful in medulloblastoma detection and a diagnostic model was established. The metabolic pathway analysis showed that there were significant differences in patients with medulloblastoma in terms of glycerophospholipid metabolism metabolism, sphingolipid metabolism and linoleic acid metabolism pathways.

Conclusion: The difference in plasma lipid markers between medulloblastoma and other intracranial tumors screened in this study may be useful to support and improve the differential diagnosis of medulloblastoma in children.

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血浆脂质组学分析识别儿童髓母细胞瘤的特征。

背景：髓母细胞瘤与儿童后颅窝常见的其他肿瘤在发病和临床表现上相似。但其主要治疗方法、手术方式及预后差异较大。因此，迫切需要寻找用于鉴别诊断的生物标志物。目的：本研究的目的是通过分析髓母细胞瘤儿童与其他颅内肿瘤患者血浆中存在的显著不同的脂质来识别新的脂质和不同的代谢途径。方法：本研究纳入了35例髓母细胞瘤患者和32例匹配的对照组。收集血浆样本和医疗记录，采用UHPLC-MS/MS进行非靶向脂质组学分析。结果：在髓母细胞瘤患儿血浆中共鉴定出97种不同的脂质。七种不同的脂质可能对髓母细胞瘤的检测有潜在的帮助，并建立了诊断模型。代谢途径分析显示，髓母细胞瘤患者在甘油磷脂代谢、鞘脂代谢和亚油酸代谢途径上存在显著差异。结论：本研究筛选的成神经管细胞瘤与其他颅内肿瘤的血浆脂质标志物的差异可能有助于支持和提高儿童成神经管细胞瘤的鉴别诊断。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Clinical & Translational Oncology 医学-肿瘤学

CiteScore

6.20

自引率

2.90%

发文量

240

审稿时长

1 months

期刊介绍： Clinical and Translational Oncology is an international journal devoted to fostering interaction between experimental and clinical oncology. It covers all aspects of research on cancer, from the more basic discoveries dealing with both cell and molecular biology of tumour cells, to the most advanced clinical assays of conventional and new drugs. In addition, the journal has a strong commitment to facilitating the transfer of knowledge from the basic laboratory to the clinical practice, with the publication of educational series devoted to closing the gap between molecular and clinical oncologists. Molecular biology of tumours, identification of new targets for cancer therapy, and new technologies for research and treatment of cancer are the major themes covered by the educational series. Full research articles on a broad spectrum of subjects, including the molecular and cellular bases of disease, aetiology, pathophysiology, pathology, epidemiology, clinical features, and the diagnosis, prognosis and treatment of cancer, will be considered for publication.