Jeongmin Lee, Jeongeun Kwak, Min-Hee Kim, Seung-Hwan Lee, Jae-Hyoung Cho, Dong-Jun Lim, Jung Min Lee, Sang-Ah Chang, Hun-Sung Kim
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引用次数: 0
Abstract
Background/aims: Metabolic dysfunction-associated steatotic liver disease (MASLD) is associated with various metabolic disorders; however, its relationship with thyroid cancer remains unclear. This study investigated the association between MASLD and the risk of thyroid cancer.
Methods: This retrospective cohort study used data from the Korean National Health Insurance Service database on individuals who underwent three or more health examinations between January 2002 and December 2015. MASLD was diagnosed using the Hepatic Steatosis Index. Participants were followed up until December 31, 2019, to assess the incidence of newly diagnosed thyroid cancer.
Results: A total of 121,479 individuals were included in this study. In the age- and sex-adjusted analysis, the risk of thyroid cancer was significantly higher in the MASLD group than in the normal group (HR 1.19, 95% CI 1.11-1.29, p < 0.001). Age was a significant effect modifier of the relationship between MASLD and thyroid cancer (p for interaction < 0.05). Among individuals aged 65 years or older, the risk of thyroid cancer was higher in the MASLD group than in the normal group (HR 1.31, 95% CI 1.00-1.72, p = 0.05), whereas in individuals younger than 65 years, MASLD was not associated with thyroid cancer (HR 0.97, 95% CI 0.89-1.04, p = 0.37).
Conclusion: This study suggests an association between MASLD and an increased risk of thyroid cancer in older adults. However, further research is needed to determine whether lifestyle modifications, such as weight management, influence thyroid cancer risk in this population.
背景/目的：代谢功能障碍相关脂肪变性肝病（MASLD）与多种代谢紊乱相关；然而，它与甲状腺癌的关系尚不清楚。本研究调查了MASLD与甲状腺癌风险之间的关系。方法：本回顾性队列研究使用了2002年1月至2015年12月期间接受过三次或以上健康检查的韩国国民健康保险服务数据库中的数据。使用肝脂肪变性指数诊断MASLD。参与者被随访至2019年12月31日，以评估新诊断的甲状腺癌的发病率。结果：本研究共纳入121479名个体。在年龄和性别调整分析中，MASLD组患甲状腺癌的风险显著高于正常组（HR 1.19, 95% CI 1.11-1.29, p < 0.001）。年龄是MASLD与甲状腺癌关系的显著影响因子（交互作用p < 0.05）。在65岁及以上的个体中，MASLD组患甲状腺癌的风险高于正常组（HR 1.31, 95% CI 1.00-1.72, p = 0.05），而在65岁以下的个体中，MASLD与甲状腺癌无关（HR 0.97, 95% CI 0.89-1.04, p = 0.37）。结论：本研究提示MASLD与老年人甲状腺癌风险增加之间存在关联。然而，需要进一步的研究来确定生活方式的改变，如体重管理，是否会影响这一人群患甲状腺癌的风险。
期刊介绍：
The Korean Journal of Internal Medicine is an international medical journal published in English by the Korean Association of Internal Medicine. The Journal publishes peer-reviewed original articles, reviews, and editorials on all aspects of medicine, including clinical investigations and basic research. Both human and experimental animal studies are welcome, as are new findings on the epidemiology, pathogenesis, diagnosis, and treatment of diseases. Case reports will be published only in exceptional circumstances, when they illustrate a rare occurrence of clinical importance. Letters to the editor are encouraged for specific comments on published articles and general viewpoints.
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