[Prevalence and associated factors of hyperuricemia in patients with type 2 diabetes in hospital settings in Dakar, Senegal].

Abstract

Introduction: hyperuricemia increases cardiovascular morbidity and mortality in type 2 diabetes (T2D). The purpose of this study was to determine the prevalence of asymptomatic hyperuricemia in a population with type 2 diabetes and its determinants.

Methods: we conducted a cross-sectional study at the Pikine National Hospital Center (CHNP) and the Abass Ndao Hospital Center (Dakar, Senegal). It involved outpatients with type 2 diabetes and without a history or symptoms of gout. Fasting blood samples were taken to measure metabolic parameters (uric acid, HbA1c, lipid profile, and magnesium levels).

Results: the study included 90 patients. The mean age was 59,6 ± 8,8 years. There were 24 men and 66 women. The average duration of diabetes was 5 years, with a median HbA1c at inclusion of 7.2%. The prevalence of hyperuricemia was 31.1% (n=28). After multivariate analysis, the factors independently associated with hyperuricemia were male sex (adjusted odds ratio [aOR]: 3.9, 95% CI: 1,3-12,1; p=0,015), and GFR below 60 ml/min (aOR: 7.7, 95% CI: 1,2-48,3; p=0,029). A significant positive correlation was found between triglyceride levels and uric acid levels (r=0.5; p<0.001). Magnesium levels were inversely correlated with uric acid levels (r=-0,3; p=0,051).

Conclusion: hyperuricemia is common in patients with type 2 diabetes. Screening is necessary, especially in male patients with impaired renal function and/or hypertriglyceridemia.