Association of longer-term versus shorter-term antihypertensives prescriptions and clinical outcomes in patients with hypertension: A population-based propensity score matching study.
IF 2.8 3区 医学Q1 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH
Tao Huang, Lin Bai, Huangqianyu Li, Peng Shen, Hongbo Lin, Hao Li, Zhiyuan Wang, Yang Xu, Luwen Shi, Xiaodong Guan
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引用次数: 0
Abstract
Introduction: Previous studies have shown that longer-term prescriptions could improve medication adherence of patients with chronic diseases. However, no evidence demonstrated the impact of a longer supply duration on patients' clinical outcomes. The objective is to estimate the association between longer-term prescriptions with patients' clinical outcomes.
Methods: A retrospective population-based propensity score-matched cohort study was conducted on the Chinese Electronic Health Records Research in Yinzhou database between January 2017 and June 2022. Prescriptions with the supply duration of antihypertensives >28 days were considered as longer-term prescriptions. The primary outcome was hospitalization for cardiovascular diseases. Secondary outcomes included medication adherence measured by medication possession ratio ≥80 % and visit frequency during the follow-up. Cox proportional hazard model and conditional logistic regression were used to estimate effects in the censored at treatment switch or discontinuation analyses.
Results: 25,625 adult hypertension patient pairs were included in the propensity score matched cohort. The median follow-up time was 180 days. Compared with patients receiving shorter-term prescriptions, lower hospitalization rates for cardiovascular diseases were observed in patients with longer-term prescriptions (hazard ratio: 0.88, 95 %CI: 0.80-0.98). The proportion of adherent patients in the longer-term group was higher than that in the shorter-term group (odds ratio: 1.91, 95 % CI: 1.84-1.98). The longer-term group also had fewer patients with ≥1 visit per month during the follow-up (odds ratio: 0.19, 95 %CI: 0.18-0.20). Subgroup and sensitive analysis showed consistent results.
Conclusions: Longer-term prescriptions can improve patients' clinical outcomes and decrease their visit frequency. Promoting longer-term prescriptions can help mitigate the challenge of limited health resources and reduce disease burden.
期刊介绍：
Research in Social and Administrative Pharmacy (RSAP) is a quarterly publication featuring original scientific reports and comprehensive review articles in the social and administrative pharmaceutical sciences. Topics of interest include outcomes evaluation of products, programs, or services; pharmacoepidemiology; medication adherence; direct-to-consumer advertising of prescription medications; disease state management; health systems reform; drug marketing; medication distribution systems such as e-prescribing; web-based pharmaceutical/medical services; drug commerce and re-importation; and health professions workforce issues.
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