Zoonotic infections due to avian Chlamydia abortus: what are we missing?

IF 20.4 1区生物学 Q1 INFECTIOUS DISEASES

Lancet Microbe Pub Date : 2025-08-20 DOI:10.1016/j.lanmic.2025.101197

Nicole Borel, David Longbottom, Gilbert Greub, Sarah Albini, Daisy Vanrompay, Karine Laroucau

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引用次数: 0

Abstract

Chlamydia abortus is an obligate intracellular bacterium primarily affecting ruminants and causing reproductive failures in sheep and goats. As a recognised zoonotic pathogen, C abortus can cause obstetric and respiratory infections in humans, with severe consequences in pregnant women and immunocompromised individuals. Previous studies have identified novel C abortus strains in avian species, closely related to the zoonotic Chlamydia psittaci, with some strains associated with cases of human pneumonia. In this Personal View, we review the evolving taxonomy of C abortus in light of these novel avian strains, propose subspecies distinctions, and describe the different zoonotic risks associated with both avian and ruminant strains. Challenges in diagnostics, host preference, and case detection are discussed, emphasising the need for a One Health approach to fully understand and mitigate these risks. With increasing reports of human C abortus infections, precise strain classification and differentiation between avian and ruminant subspecies, along with targeted surveillance, are essential to limit their zoonotic transmission.

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由禽流产衣原体引起的人畜共患感染：我们错过了什么？

流产衣原体是一种专性细胞内细菌，主要影响反刍动物，导致绵羊和山羊繁殖失败。作为一种公认的人畜共患病原体，流产C可引起人类产科和呼吸道感染，对孕妇和免疫功能低下的个体造成严重后果。先前的研究已经在禽类物种中发现了新的流产C菌株，与人畜共患鹦鹉热衣原体密切相关，其中一些菌株与人类肺炎病例有关。在本个人观点中，我们根据这些新的禽毒株回顾了abortus的进化分类，提出了亚种区分，并描述了禽毒株和反刍毒株的不同人畜共患风险。讨论了诊断、宿主偏好和病例检测方面的挑战，强调需要采用“同一个健康”方法来充分了解和减轻这些风险。随着人类流产弧菌感染报告的增加，禽和反刍亚种之间的精确毒株分类和区分以及有针对性的监测对于限制其人畜共患病传播至关重要。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Lancet Microbe Multiple-

CiteScore

27.20

自引率

0.80%

发文量

278

审稿时长

6 weeks

期刊介绍： The Lancet Microbe is a gold open access journal committed to publishing content relevant to clinical microbiologists worldwide, with a focus on studies that advance clinical understanding, challenge the status quo, and advocate change in health policy.