{"title":"Lenvatinib-Associated Non-Tuberculous Mycobacterial Pulmonary Disease: A Case Report.","authors":"Qian Wang, Lili Du, Yiming Wang, Longhui Zhang","doi":"10.1002/rcr2.70316","DOIUrl":null,"url":null,"abstract":"<p><p>A 64-year-old man, with a history of hepatocellular carcinoma and long-term oral lenvatinib treatment, was hospitalised in our institution twice due to 'cough'. During hospitalisation, the patient underwent multiple bronchoscopies, with lavage fluid sent for pathogen testing, which returned negative results. Finally, <i>Mycobacterium kansasii</i> was detected via next-generation sequencing (NGS). Considering the patient's poor hepatic reserve, we decided against initiating targeted antimicrobial therapy and discontinued lenvatinib. Two months after stopping lenvatinib, the patient's symptoms of cough and chest tightness improved. A follow-up chest computed tomography (CT) on March 18, 2025, showed resolution of the lesions.</p>","PeriodicalId":45846,"journal":{"name":"Respirology Case Reports","volume":"13 8","pages":"e70316"},"PeriodicalIF":0.8000,"publicationDate":"2025-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12365607/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Respirology Case Reports","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1002/rcr2.70316","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/8/1 0:00:00","PubModel":"eCollection","JCR":"Q4","JCRName":"RESPIRATORY SYSTEM","Score":null,"Total":0}
引用次数: 0
Abstract
A 64-year-old man, with a history of hepatocellular carcinoma and long-term oral lenvatinib treatment, was hospitalised in our institution twice due to 'cough'. During hospitalisation, the patient underwent multiple bronchoscopies, with lavage fluid sent for pathogen testing, which returned negative results. Finally, Mycobacterium kansasii was detected via next-generation sequencing (NGS). Considering the patient's poor hepatic reserve, we decided against initiating targeted antimicrobial therapy and discontinued lenvatinib. Two months after stopping lenvatinib, the patient's symptoms of cough and chest tightness improved. A follow-up chest computed tomography (CT) on March 18, 2025, showed resolution of the lesions.
期刊介绍：
Respirology Case Reports is an open-access online journal dedicated to the publication of original clinical case reports, case series, clinical images and clinical videos in all fields of respiratory medicine. The Journal encourages the international exchange between clinicians and researchers of experiences in diagnosing and treating uncommon diseases or diseases with unusual presentations. All manuscripts are peer-reviewed through a streamlined process that aims at providing a rapid turnaround time from submission to publication.
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