Usefulness of A Random Spot Urine Proteins-to-Creatinine Ratio to Screen for Increased Albuminuria in Patients with Type 1 Diabetes.

IF 1.2 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY

Reports of Biochemistry and Molecular Biology Pub Date : 2025-01-01 DOI:10.61186/rbmb.13.4.561

El Hadji Malick Ndour, Rokhaya Dione, Fatou Gueye-Tall, Sokhna Mara, Gora Fall, Coumba Kamby, El Hadji Ousmane Sene, Moustapha Djite, Nene Oumou Kesso Barry, Pape Matar Kandji, Papa Madieye Gueye, Philomene Lopez-Sall, Aynina Cisse

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引用次数: 0

Abstract

Background: Moderately increased albuminuria is a biomarker for early onset diabetic nephropathy. The aim of this study was to evaluate the performance of use proteinuria-to-creatininuria ratio (UPCR) at different cut-off to screen for increased albuminuria using albuminuria-to-creatininuria ratio (UACR) as a gold standard.

Methods: This was a cross-sectional study. A random spot urine sample was collected from patients with type 1 diabetes to measure albuminuria and total proteinuria using respectively an immunoturbidimetric and a colorimetric assay. Albuminuria was expressed as UACR and proteinuria as UPCR. The area under the curve (AUC) method and the kappa coefficient were used to compare UPCR and UACR.

Results: In 150 diabetic patients, moderately increased albuminuria was detected in 33.3% using UACR and 35.3% using UPCR at 272 mg/g. UPCR thresholds of 130, 150, 180 and 200 mg/g yielded higher detection rates than UACR. However, all UPCR cut-offs showed low diagnostic accuracy (AUC < 70%), and agreement with UACR was mild (kappa < 0.40).

Conclusions: The level of agreement between UPCR and UACR was moderate. It is not sufficient for UPCR to replace UACR to screen for increased albuminuria in patient with type 1 diabetes.

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随机点尿蛋白-肌酐比筛查1型糖尿病患者蛋白尿增加的有效性

背景：中度蛋白尿增高是早发性糖尿病肾病的生物标志物。本研究的目的是以蛋白尿与肌酐尿比（UACR）为金标准，评价在不同临界值下使用蛋白尿与肌酐尿比（UPCR）筛查蛋白尿增加的效果。方法：采用横断面研究。随机抽取1型糖尿病患者的尿样，分别用免疫比浊法和比色法测定尿白蛋白和总蛋白尿。蛋白尿表达为UACR，蛋白尿表达为UPCR。采用曲线下面积法（AUC）和kappa系数对UPCR和UACR进行比较。结果：150例糖尿病患者中，UACR组检测到蛋白尿中度增高的占33.3%，UPCR组检测到蛋白尿中度增高的占35.3%，UACR组为272 mg/g。UPCR阈值分别为130、150、180和200 mg/g，检出率高于UACR。然而，所有UPCR截止值的诊断准确性较低（AUC < 70%），与UACR的一致性较轻（kappa < 0.40）。结论：UPCR和UACR的一致程度为中等。UPCR代替UACR筛查1型糖尿病患者蛋白尿增加是不够的。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Reports of Biochemistry and Molecular Biology BIOCHEMISTRY & MOLECULAR BIOLOGY-

CiteScore

2.80

自引率

23.50%

发文量

审稿时长

10 weeks

期刊介绍： The Reports of Biochemistry & Molecular Biology (RBMB) is the official journal of the Varastegan Institute for Medical Sciences and is dedicated to furthering international exchange of medical and biomedical science experience and opinion and a platform for worldwide dissemination. The RBMB is a medical journal that gives special emphasis to biochemical research and molecular biology studies. The Journal invites original and review articles, short communications, reports on experiments and clinical cases, and case reports containing new insights into any aspect of biochemistry and molecular biology that are not published or being considered for publication elsewhere. Publications are accepted in the form of reports of original research, brief communications, case reports, structured reviews, editorials, commentaries, views and perspectives, letters to authors, book reviews, resources, news, and event agenda.