{"title":"COVID-19 Vaccine-Induced Severe Pneumonitis.","authors":"Tatsuro Suzuki, Hiromi Furuta, Misa Naganawa, Keiko Hayashi, Hiroko Kiyotoshi, Chiharu Ohta, Shigemitsu Ninomiya","doi":"10.1002/rcr2.70274","DOIUrl":null,"url":null,"abstract":"<p><p>Coronavirus disease 2019 (COVID-19) has resulted in global morbidity, mortality, and societal disruption. COVID-19 mRNA vaccination was mandatory in many countries for a period; however, severe adverse events have been observed in some individuals who received the vaccine. We report a case of COVID-19 mRNA vaccine-induced pneumonitis in a male patient whose cytokine levels were analysed prior to admission. His serum IgE level was high (347 U/mL), and several cytokines were elevated: TNFα was 1.2 pg/mL, IL-6 was 156 pg/mL, and IL-8 was 75.0 pg/mL. The patient developed severe respiratory failure requiring ventilatory support but recovered after steroid pulse therapy.</p>","PeriodicalId":45846,"journal":{"name":"Respirology Case Reports","volume":"13 8","pages":"e70274"},"PeriodicalIF":0.8000,"publicationDate":"2025-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12371123/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Respirology Case Reports","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1002/rcr2.70274","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/8/1 0:00:00","PubModel":"eCollection","JCR":"Q4","JCRName":"RESPIRATORY SYSTEM","Score":null,"Total":0}
引用次数: 0
Abstract
Coronavirus disease 2019 (COVID-19) has resulted in global morbidity, mortality, and societal disruption. COVID-19 mRNA vaccination was mandatory in many countries for a period; however, severe adverse events have been observed in some individuals who received the vaccine. We report a case of COVID-19 mRNA vaccine-induced pneumonitis in a male patient whose cytokine levels were analysed prior to admission. His serum IgE level was high (347 U/mL), and several cytokines were elevated: TNFα was 1.2 pg/mL, IL-6 was 156 pg/mL, and IL-8 was 75.0 pg/mL. The patient developed severe respiratory failure requiring ventilatory support but recovered after steroid pulse therapy.
期刊介绍：
Respirology Case Reports is an open-access online journal dedicated to the publication of original clinical case reports, case series, clinical images and clinical videos in all fields of respiratory medicine. The Journal encourages the international exchange between clinicians and researchers of experiences in diagnosing and treating uncommon diseases or diseases with unusual presentations. All manuscripts are peer-reviewed through a streamlined process that aims at providing a rapid turnaround time from submission to publication.
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