SLEEP AND NEURODEGENERATION: EXAMINING POTENTIAL PHYSIOLOGICAL MECHANISMS.

IF 2 Q4 CLINICAL NEUROLOGY

Current Sleep Medicine Reports Pub Date : 2025-12-01 Epub Date: 2025-01-03 DOI:10.1007/s40675-024-00316-6

Brice V McConnell, Yulin Deng, Brendan P Lucey

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引用次数: 0

Abstract

Purpose of the review: The purpose of this review is to provide an overview of potential mechanisms mediating the bi-directional relationship between sleep and neurodegenerative diseases such as Alzheimer's disease. We provide updates on previously proposed mechanisms and identify new mechanisms particularly concerning how sleep disturbances affect memory-related neural circuits.

Recent findings: In this review, we focus on the multiple mechanisms that potentially mediate the relationship between sleep and Alzheimer's disease. We present updates for previously hypothesized mechanisms such as sleep-related changes in production/release and clearance of amyloid-β and tau proteins as well as more recently proposed mechanisms relating to tau phosphorylation, the orexin system, astrocytes, and microglia. We also highlight how disruptions in sleep EEG oscillations that underlie memory-related neural circuits, such as slow wave activity, theta bursts, sleep spindles, and gamma ripples, change in Alzheimer's disease.

Summary: Disturbed sleep increases Alzheimer's disease risk via multiple potential mechanisms that suggest multiple targets to test approved and effective treatments of sleep disorders to prevent or delay Alzheimer's disease.

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睡眠和神经退化：检查潜在的生理机制。

综述目的：本综述的目的是概述睡眠与神经退行性疾病（如阿尔茨海默病）之间双向关系的潜在机制。我们提供了先前提出的机制的更新，并确定了新的机制，特别是关于睡眠障碍如何影响记忆相关的神经回路。最新发现：在这篇综述中，我们关注睡眠和阿尔茨海默病之间潜在的多种机制。我们更新了先前假设的机制，如淀粉样蛋白-β和tau蛋白的产生/释放和清除的睡眠相关变化，以及最近提出的与tau磷酸化、食欲素系统、星形胶质细胞和小胶质细胞有关的机制。我们还强调了在阿尔茨海默病中，作为记忆相关神经回路基础的睡眠脑电图振荡的中断，如慢波活动、θ波爆发、睡眠纺锤波和伽马波纹，是如何改变的。摘要：睡眠障碍通过多种潜在机制增加阿尔茨海默病的风险，这表明有多个目标来测试批准和有效的睡眠障碍治疗，以预防或延缓阿尔茨海默病。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current Sleep Medicine Reports Medicine-Pulmonary and Respiratory Medicine

CiteScore

2.50

自引率

5.60%

发文量

期刊介绍： Current Sleep Medicine Reports aims to review the most important, recently published articles in the field of sleep medicine. By providing clear, insightful, balanced contributions by international experts, the journal intends to serve all those involved in the care and prevention of sleep conditions. We accomplish this aim by appointing international authorities to serve as Section Editors in key subject areas such as insomnia, narcolepsy, sleep apnea, circadian rhythm disorders, and parasomnias. Section Editors, in turn, select topics for which leading experts contribute comprehensive review articles that emphasize new developments and recently published papers of major importance, highlighted by annotated reference lists. An international Editorial Board reviews the annual table of contents, suggests articles of special interest to their country/region, and ensures that topics are current and include emerging research. Commentaries from well-known figures in the field are also occasionally provided.