Drug-Coated Balloons for Coronary Artery Disease: From Theory to Practice.

IF 0.6 Q4 CARDIAC & CARDIOVASCULAR SYSTEMS

Current Treatment Options in Cardiovascular Medicine Pub Date : 2025-12-01 Epub Date: 2025-03-19 DOI:10.1007/s11936-025-01084-4

Mohamad B Moumneh, Yasser Jamil, Michael G Nanna, Abdulla A Damluji

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引用次数: 0

Abstract

Purpose of review: The purpose of this work is to review the role of drug-coated balloons (DCBs) in contemporary coronary artery disease (CAD) management by focusing on its clinical indications and technical considerations, supported by updated insights from the International DCB Consensus Group.

Recent findings: While percutaneous coronary intervention (PCI) and drug-eluting stents were initially the standard treatment for CAD, limitations such in-stent stenosis, neoatherosclerosis, and increased bleeding led to the development of the novel DCBs. These DCBs have become well established in treating various clinical cases such as in-stent restenosis, de-novo small-vessel disease, bifurcation lesions, large-vessel disease, high bleeding risk, acute coronary syndromes, and diabetes mellitus.

Summary: For optimal DCB outcomes, functional assessments, careful lesion preparation, and patient selection are crucial for effective drug delivery and reduced complications. Ongoing innovations in drug formulations, balloon design, and delivery mechanisms, along with further trials, will expand DCBs' impact in CAD treatment.

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冠状动脉疾病药物包被气球：从理论到实践。

综述目的：本研究的目的是通过关注药物包覆气球（DCBs）的临床适应症和技术考虑，在国际DCB共识小组的最新见解的支持下，回顾药物包覆气球（DCBs）在当代冠状动脉疾病（CAD）管理中的作用。最近发现：虽然经皮冠状动脉介入治疗（PCI）和药物洗脱支架最初是CAD的标准治疗方法，但支架内狭窄、新动脉粥样硬化和出血增加等局限性导致了新型DCBs的发展。在治疗支架内再狭窄、新生小血管疾病、分叉病变、大血管疾病、高危出血、急性冠状动脉综合征、糖尿病等各种临床病例中，这些dcb已经得到了很好的应用。摘要：为了获得最佳的DCB结果，功能评估、仔细的病变准备和患者选择是有效给药和减少并发症的关键。药物配方、气囊设计和给药机制的持续创新，以及进一步的试验，将扩大dcb在CAD治疗中的影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current Treatment Options in Cardiovascular Medicine Medicine-Cardiology and Cardiovascular Medicine

CiteScore

2.00

自引率

0.00%

发文量

期刊介绍： This journal aims to review the most important, recently published treatment-related advances in cardiovascular medicine. By providing clear, insightful, balanced contributions by international experts, the journal intends to elucidate novel approaches to treatment in those affected by the spectrum of cardiovascular-related diseases and conditions. We accomplish this aim by appointing international authorities to serve as Section Editors in key subject areas, such as coronary artery disease, cerebrovascular disease and stroke, heart failure, pediatric and congenital heart disease, and valvular, myocardial, pericardial, and cardiopulmonary diseases. Section Editors, in turn, select topics for which leading experts contribute comprehensive review articles that emphasize new developments and recently published papers of major importance, highlighted by annotated reference lists. We also provide commentaries from well-known figures in the field, and an international Editorial Board reviews the annual table of contents, suggests articles of special interest to their country/region, and ensures that topics are current and include emerging research.