Neutrophil-Lymphocyte Ratio and Platelet-Lymphocyte Ratio in ADHD: A Systematic Scoping Review.

IF 1.5 Q3 EDUCATION, SPECIAL

Advances in Neurodevelopmental Disorders Pub Date : 2024-12-18 DOI:10.1007/s41252-024-00433-x

Taryn A Machingo, Alisha M Bruton, Jennifer J Ryan, Jeanette M Johnstone

{"title":"Neutrophil-Lymphocyte Ratio and Platelet-Lymphocyte Ratio in ADHD: A Systematic Scoping Review.","authors":"Taryn A Machingo, Alisha M Bruton, Jennifer J Ryan, Jeanette M Johnstone","doi":"10.1007/s41252-024-00433-x","DOIUrl":null,"url":null,"abstract":"Objectives: Neutrophil-lymphocyte and platelet-lymphocyte ratio (NLR, PLR) are easily calculated from routine blood tests and are increasingly being used in research to assess disease severity in inflammatory, infectious, and psychiatric conditions. The goal of this systematic scoping review was to broadly examine the literature on NLR and PLR and attention-deficit/hyperactivity disorder (ADHD).Methods: The PubMed/Medline, PsychInfo, Scopus, Embase, Cochrane Central Register of Controlled Trials, Cumulative Index to Nursing and Allied Health Literature, ClinicalTrials.gov, World Health Organization International Clinical Trials Registry Platform, International Standard Randomized Controlled Trial Number, Google Scholar, Directory of Open Access Journals, and ProQuest databases were searched.Results: Among the 1542 articles evaluated, 15 were included. Fourteen studies evaluated children and adolescents with ADHD and one study evaluated adults. Study outcomes included the comparison of mean NLR and PLR values between ADHD and non-ADHD groups and the association of NLR and PLR values with measures of ADHD symptom severity. Four studies used receiver operating characteristic (ROC) curves to identify potential cut points for the diagnosis of ADHD. Assessing NLR and PLR is economical and minimally invasive.Conclusions: Based on the 15 studies reviewed, findings suggest NLR and PLR may be promising biomarkers for ADHD. Additional research is justified to further investigate if routine incorporation of NLR and PLR into research and clinical practice could beneficially impact the diagnosis and treatment of patients with ADHD.","PeriodicalId":36163,"journal":{"name":"Advances in Neurodevelopmental Disorders","volume":" ","pages":""},"PeriodicalIF":1.5000,"publicationDate":"2024-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12382606/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Advances in Neurodevelopmental Disorders","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1007/s41252-024-00433-x","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"EDUCATION, SPECIAL","Score":null,"Total":0}

引用次数: 0

Abstract

Objectives: Neutrophil-lymphocyte and platelet-lymphocyte ratio (NLR, PLR) are easily calculated from routine blood tests and are increasingly being used in research to assess disease severity in inflammatory, infectious, and psychiatric conditions. The goal of this systematic scoping review was to broadly examine the literature on NLR and PLR and attention-deficit/hyperactivity disorder (ADHD).

Methods: The PubMed/Medline, PsychInfo, Scopus, Embase, Cochrane Central Register of Controlled Trials, Cumulative Index to Nursing and Allied Health Literature, ClinicalTrials.gov, World Health Organization International Clinical Trials Registry Platform, International Standard Randomized Controlled Trial Number, Google Scholar, Directory of Open Access Journals, and ProQuest databases were searched.

Results: Among the 1542 articles evaluated, 15 were included. Fourteen studies evaluated children and adolescents with ADHD and one study evaluated adults. Study outcomes included the comparison of mean NLR and PLR values between ADHD and non-ADHD groups and the association of NLR and PLR values with measures of ADHD symptom severity. Four studies used receiver operating characteristic (ROC) curves to identify potential cut points for the diagnosis of ADHD. Assessing NLR and PLR is economical and minimally invasive.

Conclusions: Based on the 15 studies reviewed, findings suggest NLR and PLR may be promising biomarkers for ADHD. Additional research is justified to further investigate if routine incorporation of NLR and PLR into research and clinical practice could beneficially impact the diagnosis and treatment of patients with ADHD.

查看原文本刊更多论文

中性粒细胞-淋巴细胞比率和血小板-淋巴细胞比率在多动症：一个系统的范围审查。

目的：中性粒细胞-淋巴细胞和血小板-淋巴细胞比值（NLR， PLR）很容易从常规血液检查中计算出来，并且越来越多地用于研究炎症、感染性疾病和精神疾病的严重程度。本系统综述的目的是对NLR和PLR与注意缺陷/多动障碍（ADHD）的文献进行广泛的研究。方法：检索PubMed/Medline、PsychInfo、Scopus、Embase、Cochrane Central Register of Controlled Trials、Cumulative Index to Nursing and Allied Health Literature、ClinicalTrials.gov、World Health Organization国际临床试验注册平台、国际标准随机对照试验号、谷歌Scholar、Directory of Open Access Journals、ProQuest数据库。结果：1542篇被评估的文献中，有15篇被纳入。14项研究评估了患有多动症的儿童和青少年，1项研究评估了成年人。研究结果包括ADHD组和非ADHD组的NLR和PLR平均值的比较，以及NLR和PLR值与ADHD症状严重程度的相关性。四项研究使用受试者工作特征（ROC）曲线来确定ADHD诊断的潜在切点。评估NLR和PLR是经济且微创的。结论：根据回顾的15项研究，研究结果表明NLR和PLR可能是有希望的ADHD生物标志物。我们有理由进一步研究将NLR和PLR常规纳入研究和临床实践是否对ADHD患者的诊断和治疗有益。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Advances in Neurodevelopmental Disorders Social Sciences-Social Sciences (miscellaneous)

CiteScore

2.10

自引率

0.00%

发文量

期刊介绍： Advances in Neurodevelopmental Disorders publishes high-quality research in the broad area of neurodevelopmental disorders across the lifespan. Study participants may include individuals with:Intellectual and developmental disabilitiesGlobal developmental delayCommunication disordersLanguage disordersSpeech sound disordersChildhood-onset fluency disorders (e.g., stuttering)Social (e.g., pragmatic) communication disordersUnspecified communication disordersAutism spectrum disorder (ASD)Attention-deficit/hyperactivity disorder (ADHD), specified and unspecifiedSpecific learning disordersMotor disordersDevelopmental coordination disordersStereotypic movement disorderTic disorders, specified and unspecifiedOther neurodevelopmental disorders, specified and unspecifiedPapers may also include studies of participants with neurodegenerative disorders that lead to a decline in intellectual functioning, including Alzheimer’s disease, amyotrophic lateral sclerosis, Creutzfeldt-Jakob disease, vascular dementia, Lewy body dementia, frontotemporal dementia, corticobasal degeneration, Huntington’s disease, and progressive supranuclear palsy. The journal includes empirical, theoretical and review papers on a large variety of issues, populations, and domains, including but not limited to: diagnosis; incidence and prevalence; and educational, pharmacological, behavioral and cognitive behavioral, mindfulness, and psychosocial interventions across the life span. Animal models of basic research that inform the understanding and treatment of neurodevelopmental disorders are also welcomed. The journal is multidisciplinary and multi-theoretical, and encourages research from multiple specialties in the social sciences using quantitative and mixed-method research methodologies.