Yu-Zhu Chen, Yu-Ting Wei, Min Xiao, Wen-Ting Xie, Xing-Ke Yan
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引用次数: 0
Abstract
Acupuncture has a definite effect on the treatment of Alzheimer's disease (AD), and its molecular mechanism has been studied more and more deeply. The phosphatidylinositol 3-kinase/protein kinase B (PI3K/AKT) signaling pathway is mainly involved in the regulation of cell proliferation, apoptosis, autophagy and synaptic plasticity, and plays an important role in the occurrence and development of AD. In this paper, we reviewed the role of PI3K/AKT pathway in the pathogenesis of AD and the mechanism of acupuncture intervention, and concluded that the abnormal expression of PI3K/AKT signaling pathway can lead to imbalance of cellular oxidative defense system, impairment of mitochondrial structure and function synaptic destruction, abnormal autophagy and energy metabolism disorders, and acupuncture can improve oxidative stress damage, enhance synaptic plasticity, regulate autophagic activity and regulate energy metabolism by regulating PI3K/AKT signaling pathway to cure AD.
期刊介绍：
Acupuncture Research was founded in 1976. It is an acupuncture academic journal supervised by the State Administration of Traditional Chinese Medicine, co-sponsored by the Institute of Acupuncture of the China Academy of Chinese Medical Sciences and the Chinese Acupuncture Association. This journal is characterized by "basic experimental research as the main focus, taking into account clinical research and reporting". It is the only journal in my country that focuses on reporting the mechanism of action of acupuncture.
The journal has been changed to a monthly journal since 2018, published on the 25th of each month, and printed in full color. The manuscript acceptance rate is about 10%, and provincial and above funded projects account for about 80% of the total published papers, reflecting the latest scientific research results in the acupuncture field and has a high academic level. Main columns: mechanism discussion, clinical research, acupuncture anesthesia, meridians and acupoints, theoretical discussion, ideas and methods, literature research, etc.
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