Merkel cell carcinoma presenting as a nasal dorsum mass: A case report and literature review.

IF 1 4区医学 Q3 MEDICINE, GENERAL & INTERNAL

World Journal of Clinical Cases Pub Date : 2025-08-26 DOI:10.12998/wjcc.v13.i24.105244

Abdullah Ibrahim Ali Abuharb, Abdullah Fahad Alzamil, Khalid Saad Alqarni, Ali M Alsudays, Saeed M Alqahtani, Rawan Mosleh Alahmadi, Alyaa Shojaa Al Mutairy, Fareed Ramzi Alghamdi

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引用次数: 0

Abstract

Background: Merkel cell carcinoma (MCC) is a rare and aggressive skin cancer with high incidence in older and immunocompromised patients. Its occurrence in the nasal dorsum is extremely rare and poses significant diagnostic and therapeutic challenges.

Case summary: We report the case of a 65-year-old woman with diabetes mellitus and hypertension who presented with a dorsal nasal mass. The initial differential diagnosis favored hemangioma-based clinical examination on imaging. Histopathological examination after excision revealed MCC, necessitating a complex management strategy. A 3 cm × 2 cm nasal mass, initially suspected to be a hemangioma, was excised but revealed MCC with positive margins. Positron emission tomography-computed tomography confirmed metastatic cervical lymphadenopathy. The patient underwent bilateral neck dissection, revealing metastases in seven nodes. Residual activity was treated with radiation therapy, leading to a favorable response after 6 months.

Conclusion: This case highlights the importance of considering MCC in the differential diagnosis of nasal masses, and integrated management.

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默克尔细胞癌表现为鼻背肿块：1例报告及文献复习。

背景：默克尔细胞癌（MCC）是一种罕见的侵袭性皮肤癌，在老年人和免疫功能低下患者中发病率高。其发生在鼻背是极其罕见的，并提出了重大的诊断和治疗挑战。病例总结：我们报告一例65岁女性糖尿病和高血压谁提出了一个背鼻肿块。最初的鉴别诊断倾向于基于血管瘤的临床影像学检查。切除后的组织病理学检查显示MCC，需要复杂的管理策略。一个3cm × 2cm的鼻肿块，最初怀疑是血管瘤，切除后发现MCC边缘呈阳性。正电子发射断层扫描-计算机断层扫描证实转移性宫颈淋巴结病。患者行双侧颈部清扫，发现7个淋巴结转移。残留活性用放射疗法治疗，6个月后出现良好反应。结论：本病例强调了MCC在鼻肿块鉴别诊断和综合治疗中的重要性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

World Journal of Clinical Cases Medicine-General Medicine

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3384

期刊介绍： The World Journal of Clinical Cases (WJCC) is a high-quality, peer reviewed, open-access journal. The primary task of WJCC is to rapidly publish high-quality original articles, reviews, editorials, and case reports in the field of clinical cases. In order to promote productive academic communication, the peer review process for the WJCC is transparent; to this end, all published manuscripts are accompanied by the anonymized reviewers’ comments as well as the authors’ responses. The primary aims of the WJCC are to improve diagnostic, therapeutic and preventive modalities and the skills of clinicians and to guide clinical practice in clinical cases.