Role of nitric oxide, prostaglandins, thromboxanes and endothelins in lung cancer: An overview.

IF 1 4区医学 Q3 MEDICINE, GENERAL & INTERNAL

World Journal of Clinical Cases Pub Date : 2025-09-06 DOI:10.12998/wjcc.v13.i25.107907

Sadettin Demirel, Ipek Nazli Sinag

{"title":"Role of nitric oxide, prostaglandins, thromboxanes and endothelins in lung cancer: An overview.","authors":"Sadettin Demirel, Ipek Nazli Sinag","doi":"10.12998/wjcc.v13.i25.107907","DOIUrl":null,"url":null,"abstract":"Lung cancer is the most frequent cause of cancer-related mortality worldwide. Nitric oxide (NO), prostaglandins (PGs), thromboxanes (TXs), and endothelins (ETs) participate in numerous physiological processes. These agents play an important role in lung carcinogenesis by regulating cancer cell proliferation, apoptosis, invasion, and angiogenesis. NO is a gaseous free radical with tumoricidal and tumorigenic activities in lung cancer. Arachidonic acid-derived PGs, including PGD2, PGE2, 8-iso-PGF2α, and PGI2, are related to the development of lung cancer. PGD2 and PGI2 act as tumor suppressors, while PGE2 and 8-iso-PGF2α promote tumor progression. TXA2 catalyzed by cyclooxygenase induces proliferation as well as angiogenesis. Elevated levels of TXB2, an inactive metabolite of TXA2, are positively correlated with lung carcinoma stages. ET-1 and ET-2 are 21 amino acid polypeptides; their silencing hinders lung cancer cell proliferation and invasion. ET-2 depletion also triggers apoptotic death. This chapter review aims to provide a comprehensive overview of the role of NO, PGs, TXs, and ETs in lung cancer.","PeriodicalId":23912,"journal":{"name":"World Journal of Clinical Cases","volume":"13 25","pages":"107907"},"PeriodicalIF":1.0000,"publicationDate":"2025-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12243923/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"World Journal of Clinical Cases","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.12998/wjcc.v13.i25.107907","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"MEDICINE, GENERAL & INTERNAL","Score":null,"Total":0}

引用次数: 0

Abstract

Lung cancer is the most frequent cause of cancer-related mortality worldwide. Nitric oxide (NO), prostaglandins (PGs), thromboxanes (TXs), and endothelins (ETs) participate in numerous physiological processes. These agents play an important role in lung carcinogenesis by regulating cancer cell proliferation, apoptosis, invasion, and angiogenesis. NO is a gaseous free radical with tumoricidal and tumorigenic activities in lung cancer. Arachidonic acid-derived PGs, including PGD₂, PGE₂, 8-iso-PGF_2α, and PGI₂, are related to the development of lung cancer. PGD₂ and PGI₂ act as tumor suppressors, while PGE₂ and 8-iso-PGF_2α promote tumor progression. TXA₂ catalyzed by cyclooxygenase induces proliferation as well as angiogenesis. Elevated levels of TXB₂, an inactive metabolite of TXA₂, are positively correlated with lung carcinoma stages. ET-1 and ET-2 are 21 amino acid polypeptides; their silencing hinders lung cancer cell proliferation and invasion. ET-2 depletion also triggers apoptotic death. This chapter review aims to provide a comprehensive overview of the role of NO, PGs, TXs, and ETs in lung cancer.

Abstract Image

查看原文本刊更多论文

一氧化氮、前列腺素、血栓素和内皮素在肺癌中的作用综述。

肺癌是全世界癌症相关死亡的最常见原因。一氧化氮（NO）、前列腺素（pg）、血栓素（TXs）和内皮素（ETs）参与了许多生理过程。这些药物通过调节癌细胞增殖、凋亡、侵袭和血管生成在肺癌发生过程中发挥重要作用。NO是一种在肺癌中具有杀瘤和致瘤活性的气态自由基。花生四烯酸衍生的PGs，包括PGD2、PGE2、8-iso-PGF2α和PGI2，与肺癌的发展有关。PGD2和PGI2作为肿瘤抑制因子，而PGE2和8-iso-PGF2α促进肿瘤进展。环氧化酶催化的TXA2可诱导细胞增殖和血管生成。TXB2 （TXA2的无活性代谢物）水平升高与肺癌分期呈正相关。ET-1和ET-2是21个氨基酸多肽；它们的沉默阻碍了肺癌细胞的增殖和侵袭。ET-2耗竭也会引发细胞凋亡。本章综述旨在全面概述NO、pg、TXs和ETs在肺癌中的作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

World Journal of Clinical Cases Medicine-General Medicine

自引率

0.00%

发文量

3384

期刊介绍： The World Journal of Clinical Cases (WJCC) is a high-quality, peer reviewed, open-access journal. The primary task of WJCC is to rapidly publish high-quality original articles, reviews, editorials, and case reports in the field of clinical cases. In order to promote productive academic communication, the peer review process for the WJCC is transparent; to this end, all published manuscripts are accompanied by the anonymized reviewers’ comments as well as the authors’ responses. The primary aims of the WJCC are to improve diagnostic, therapeutic and preventive modalities and the skills of clinicians and to guide clinical practice in clinical cases.