Correlation between baseline magnetic resonance imaging features and serum carcinoembryonic antigen levels in patients with primary rectal cancer.

IF 2.5 4区医学 Q2 GASTROENTEROLOGY & HEPATOLOGY

World Journal of Gastrointestinal Oncology Pub Date : 2025-08-15 DOI:10.4251/wjgo.v17.i8.108016

Peng Wang, Wen-Na Zhao, Jun Han, Kai-Xuan Wang, Xiao-Feng Yang, Yi-Juan Huang

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引用次数: 0

Abstract

Background: Serum carcinoembryonic antigen (CEA) levels and magnetic resonance imaging (MRI) findings are widely used for the diagnosis and treatment of rectal cancer; however, research investigating their correlation remains limited.

Aim: To investigate the correlation between baseline MRI features and serum CEA levels in patients diagnosed with primary rectal cancer.

Methods: Eighty patients (age: 42-78 years) diagnosed with primary rectal cancer were enrolled. Baseline MRI examinations were performed to evaluate tumor size, T stage, circumferential resection margin status, extramural vascular invasion (EMVI), and lymph node metastasis. Serum CEA levels were concurrently measured. Statistical methods were used to analyze correlations.

Results: Tumor size, T stage, EMVI, and lymph node metastasis were significantly correlated with serum CEA levels (P < 0.05). Multivariate analysis identified T stage and lymph node metastasis as independent factors influencing serum CEA levels.

Conclusion: This study confirmed the correlation between baseline MRI features and serum CEA levels in patients with primary rectal cancer, highlighting their potential utility for precise diagnosis, staging, and prognostic evaluation.

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原发性直肠癌患者基线磁共振成像特征与血清癌胚抗原水平的相关性

背景：血清癌胚抗原（CEA）水平和磁共振成像（MRI）结果被广泛用于直肠癌的诊断和治疗；然而，调查它们之间相关性的研究仍然有限。目的：探讨原发性直肠癌患者MRI基线特征与血清CEA水平的相关性。方法：入选原发性直肠癌患者80例，年龄42 ~ 78岁。基线MRI检查评估肿瘤大小、T分期、环切缘状态、外血管侵犯（EMVI）和淋巴结转移。同时测定血清CEA水平。采用统计学方法分析相关性。结果：肿瘤大小、T分期、EMVI、淋巴结转移与血清CEA水平有显著相关性（P < 0.05）。多因素分析发现T分期和淋巴结转移是影响血清CEA水平的独立因素。结论：本研究证实了原发性直肠癌患者的基线MRI特征与血清CEA水平之间的相关性，强调了它们在精确诊断、分期和预后评估方面的潜在效用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

World Journal of Gastrointestinal Oncology Medicine-Gastroenterology

CiteScore

4.20

自引率

3.30%

发文量

1082

期刊介绍： The World Journal of Gastrointestinal Oncology (WJGO) is a leading academic journal devoted to reporting the latest, cutting-edge research progress and findings of basic research and clinical practice in the field of gastrointestinal oncology.