Anna T Carroll, Rachel A Reed, Michael Perlini, Amara E Clough, Matheus Rocha, Valerie J Moorman
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引用次数: 0
Abstract
Objective: To evaluate the effect of cervical epidural injection of morphine alone and morphine in combination with detomidine on recovery from anesthesia in horses.
Study design: Blinded, randomized, crossover, Latin square design.
Animals: A group of six healthy adult horses aged 9 ± 3 years and weighing 471 ± 76 kg (mean ± standard deviation).
Methods: Horses were administered each of three treatments during a 1 hour general anesthetic with a 4 day washout period. Treatments were: 1) cervical epidural injection of saline 0.011 mL kg-1 (S); 2) morphine 0.1 mg kg-1 (M); and 3) morphine 0.1 mg kg-1 with detomidine 0.01 mg kg-1 (MD). Data evaluating the quality of rope-assisted anesthetic recovery included accelerometry-based recovery score, time to first movement, time to sternal recumbency, time to standing and number of attempts to stand. Data were analyzed using a generalized linear mixed model. Significance was set at p < 0.05.
Results: Recovery scores were 24.4 ± 10.0, 23.9 ± 6.7 and 19.9 ± 7.7 for treatments S, M and MD, respectively (p = 0.463). Times for first movement, sternal recumbency and standing were 33 ± 16, 22 ± 18 and 45 ± 10 minutes; 48 ± 26, 57 ± 29 and 69 ± 25 minutes; and 55 ± 20, 61 ± 28 and 70 ± 23 minutes for treatments S, M and MD, respectively.
Conclusions: Cervical epidural injection of morphine alone and morphine with detomidine did not negatively affect recovery compared with saline.
Clinical relevance: The use of cervical epidural injection of morphine alone or morphine in combination with detomidine does not negatively affect the recovery quality of horses from general anesthesia.
期刊介绍：
Veterinary Anaesthesia and Analgesia is the official journal of the Association of Veterinary Anaesthetists, the American College of Veterinary Anesthesia and Analgesia and the European College of Veterinary Anaesthesia and Analgesia. Its purpose is the publication of original, peer reviewed articles covering all branches of anaesthesia and the relief of pain in animals. Articles concerned with the following subjects related to anaesthesia and analgesia are also welcome:
the basic sciences;
pathophysiology of disease as it relates to anaesthetic management
equipment
intensive care
chemical restraint of animals including laboratory animals, wildlife and exotic animals
welfare issues associated with pain and distress
education in veterinary anaesthesia and analgesia.
Review articles, special articles, and historical notes will also be published, along with editorials, case reports in the form of letters to the editor, and book reviews. There is also an active correspondence section.
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