Intralipid emulsion therapy for ivermectin toxicity in a dog.

IF 1.7 3区农林科学 Q2 VETERINARY SCIENCES

Veterinary Medicine and Science Pub Date : 2025-09-01 DOI:10.1002/vms3.70586

Ehsan Khaksar, Hamed Karimi, Mahdieh Rezaei, Salar Zehforosh

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Abstract

Objective: Therapeutic management of ivermectin overdose in a Shih Tzu dog using intravenous administration of intravenous lipid emulsion (ILE).

Case summary: A 3-year-old female Shih Tzu dog weighing 2.5 kg was presented to a veterinary clinic in Tehran with ataxia, tremors, incoordination, negative PLR and menace reflex, bradycardia and salivation. The patient was treated with a 10 mg ivermectin tablet with the brand name Medimect in the last 12 h. Following the diagnosis of ivermectin intoxication, treatment with ILE was initiated. ILE was administered as a bolus of 1.5 mL/kg in 1 min, followed by a dose of 0.25 mL/kg/min for 30 min as a CRI. The neurological symptoms of the patient began to decrease 2.5 h after the ILE therapy. Twenty-four hours later, the patient was resuscitated, and all symptoms were resolved.

Conclusion: The current paper reports the successful treatment of ivermectin toxicity with ILE therapy in Iran. The education of veterinarians regarding the beneficial and varied roles of ILE therapy in different clinical settings is warranted, particularly in terms of the potential for ILE therapy to reverse the toxicities of various lipophilic drugs.

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脂内乳剂治疗犬伊维菌素中毒。

目的：静脉注射脂质乳治疗西施犬伊维菌素过量。病例总结：一只体重2.5 kg的3岁雌性西犬被送到德黑兰的一家兽医诊所，患有共济失调、震颤、不协调、PLR阴性和威胁反射、心动过缓和流涎。患者在最后12小时内服用了品牌为Medimect的10mg伊维菌素片。在诊断为伊维菌素中毒后，开始了ILE治疗。ILE在1分钟内以1.5 mL/kg的剂量给药，然后以0.25 mL/kg/min的剂量给药，持续30分钟作为CRI。ILE治疗后2.5 h，患者神经系统症状开始减轻。24小时后，患者复苏，所有症状消失。结论：本文报道了在伊朗用ILE疗法成功治疗伊维菌素毒性。对兽医进行有关ILE治疗在不同临床环境中有益和不同作用的教育是必要的，特别是在ILE治疗逆转各种亲脂药物毒性的潜力方面。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Veterinary Medicine and Science Veterinary-General Veterinary

CiteScore

3.00

自引率

0.00%

发文量

296

期刊介绍： Veterinary Medicine and Science is the peer-reviewed journal for rapid dissemination of research in all areas of veterinary medicine and science. The journal aims to serve the research community by providing a vehicle for authors wishing to publish interesting and high quality work in both fundamental and clinical veterinary medicine and science. Veterinary Medicine and Science publishes original research articles, systematic reviews, meta-analyses, and research methods papers, along with invited editorials and commentaries. Original research papers must report well-conducted research with conclusions supported by the data presented in the paper. We aim to be a truly global forum for high-quality research in veterinary medicine and science, and believe that the best research should be published and made widely accessible as quickly as possible. Veterinary Medicine and Science publishes papers submitted directly to the journal and those referred from a select group of prestigious journals published by Wiley-Blackwell. Veterinary Medicine and Science is a Wiley Open Access journal, one of a new series of peer-reviewed titles publishing quality research with speed and efficiency. For further information visit the Wiley Open Access website.