The association between frailty index and all-cause mortality in US individuals with kidney stones: mediation by systemic immune-inflammation (SII) index.

IF 2.2 2区医学 Q2 UROLOGY & NEPHROLOGY

Urolithiasis Pub Date : 2025-08-31 DOI:10.1007/s00240-025-01837-7

Shuangning Liu, Yu Dai, YanHu Meng, Jie Zhang, Xiaoke Sun, Yatao Jia

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Abstract

The relationship between the frailty index (FI) and all-cause mortality in patients with kidney stones remains unclear, and whether this relationship is mediated by the systemic Immune-Inflammation index (SII). This cohort study analyzed data from the National Health and Nutrition Examination Survey (NHANES) in the United States, spanning 2007 to 2018. Utilizing Kaplan-Meier survival curves, Cox regression analysis, restricted cubic splines (RCS), and mediation analysis, the research investigated the relationships between FI, SII, and all-cause mortality in individuals with kidney stones. During a median follow-up of 6.3 years (16695 person-years) ,356 total deaths were recorded. A cohort of 2,620 U.S. participants was enrolled from NHANES 2007-2018. Frail individuals demonstrated significantly higher all-cause mortality compared to non-frail counterparts (HR = 1.78, 95% CI: 1.56-2.02, P < 0 0.001). Among patients with kidney stones, the FI showed a positive correlation with the SII (β = 38.18, 95% CI: 10.38-65.99, P < 0.01). The SII indirectly influenced the FI and all-cause mortality in these patients, accounting for 5.6% of the mediating effect. Among U.S. adults with kidney stones, the FI is linked to a higher risk of all-cause mortality, with SII potentially serving as a biological mechanism.

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美国肾结石患者虚弱指数与全因死亡率之间的关系：由全身免疫炎症（SII）指数介导。

肾结石患者虚弱指数（FI）与全因死亡率之间的关系尚不清楚，以及这种关系是否由全身免疫炎症指数（SII）介导。这项队列研究分析了2007年至2018年美国国家健康与营养检查调查（NHANES）的数据。利用Kaplan-Meier生存曲线、Cox回归分析、限制性三次样条（RCS）和中介分析，研究肾结石患者FI、SII和全因死亡率之间的关系。在中位随访6.3年（16695人年）期间，共记录了356例死亡。从2007-2018年的NHANES中招募了2620名美国参与者。体弱个体的全因死亡率明显高于非体弱个体(HR = 1.78, 95% CI: 1.56-2.02， P

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来源期刊

Urolithiasis UROLOGY & NEPHROLOGY-

CiteScore

4.50

自引率

6.50%

发文量

期刊介绍： Official Journal of the International Urolithiasis Society The journal aims to publish original articles in the fields of clinical and experimental investigation only within the sphere of urolithiasis and its related areas of research. The journal covers all aspects of urolithiasis research including the diagnosis, epidemiology, pathogenesis, genetics, clinical biochemistry, open and non-invasive surgical intervention, nephrological investigation, chemistry and prophylaxis of the disorder. The Editor welcomes contributions on topics of interest to urologists, nephrologists, radiologists, clinical biochemists, epidemiologists, nutritionists, basic scientists and nurses working in that field. Contributions may be submitted as full-length articles or as rapid communications in the form of Letters to the Editor. Articles should be original and should contain important new findings from carefully conducted studies designed to produce statistically significant data. Please note that we no longer publish articles classified as Case Reports. Editorials and review articles may be published by invitation from the Editorial Board. All submissions are peer-reviewed. Through an electronic system for the submission and review of manuscripts, the Editor and Associate Editors aim to make publication accessible as quickly as possible to a large number of readers throughout the world.