{"title":"The Observation of Peripapillary Hyperreflective Ovoid Mass-Like Structures in Adolescents by Swept-Source Optical Coherence Tomography Angiography.","authors":"Di Xiao, Dihao Hua, Lhamo Tsering, Fangyuan Zhou, Yilin Yuan, Changzheng Chen, Yishuang Xu","doi":"10.1167/tvst.14.8.34","DOIUrl":null,"url":null,"abstract":"<p><strong>Purpose: </strong>To present the swept-source optical coherence tomography angiography (SS-OCTA) characteristics of peripapillary hyperreflective ovoid mass-like structures (PHOMS) in healthy adolescents and evaluate the effects of PHOMS on peripapillary structural and microvascular parameters.</p><p><strong>Methods: </strong>A total of 218 eyes of 117 healthy adolescents were included. SS-OCTA images centered on the optic nerve head (ONH) were captured on eyes included. Structural characteristics of the ONH were compared between adolescents with or without PHOMS. After a propensity score matching was conducted, the alterations of peripapillary structures and capillaries in adolescents with PHOMS were analyzed.</p><p><strong>Results: </strong>PHOMS were found in 33.5% of the adolescent eyes. OCTA showed blood flow signals within all PHOMS. Large ONH tilt angle and small cup-to-disc ratio were independent risk factors for PHOMS (P < 0.001), and they were closely related to the size of PHOMS (P < 0.01). Thickened peripapillary retinal nerve fiber layer and elevated radial peripapillary capillary vessel density were observed in adolescents with PHOMS, especially in those with large PHOMS (all P < 0.05).</p><p><strong>Conclusions: </strong>PHOMS, complex structures containing nerve fibers and vascular networks, were common in adolescents. The presence of PHOMS in healthy individuals was closely related to the structural features of ONH. PHOMS were usually accompanied by congested and dilated nerve fibers and radial peripapillary capillaries.</p><p><strong>Translational relevance: </strong>This study provides new insights into the composition of PHOMS and their effects on peripapillary structures and capillaries.</p>","PeriodicalId":23322,"journal":{"name":"Translational Vision Science & Technology","volume":"14 8","pages":"34"},"PeriodicalIF":2.6000,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12372947/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Translational Vision Science & Technology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1167/tvst.14.8.34","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"OPHTHALMOLOGY","Score":null,"Total":0}
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Abstract
Purpose: To present the swept-source optical coherence tomography angiography (SS-OCTA) characteristics of peripapillary hyperreflective ovoid mass-like structures (PHOMS) in healthy adolescents and evaluate the effects of PHOMS on peripapillary structural and microvascular parameters.
Methods: A total of 218 eyes of 117 healthy adolescents were included. SS-OCTA images centered on the optic nerve head (ONH) were captured on eyes included. Structural characteristics of the ONH were compared between adolescents with or without PHOMS. After a propensity score matching was conducted, the alterations of peripapillary structures and capillaries in adolescents with PHOMS were analyzed.
Results: PHOMS were found in 33.5% of the adolescent eyes. OCTA showed blood flow signals within all PHOMS. Large ONH tilt angle and small cup-to-disc ratio were independent risk factors for PHOMS (P < 0.001), and they were closely related to the size of PHOMS (P < 0.01). Thickened peripapillary retinal nerve fiber layer and elevated radial peripapillary capillary vessel density were observed in adolescents with PHOMS, especially in those with large PHOMS (all P < 0.05).
Conclusions: PHOMS, complex structures containing nerve fibers and vascular networks, were common in adolescents. The presence of PHOMS in healthy individuals was closely related to the structural features of ONH. PHOMS were usually accompanied by congested and dilated nerve fibers and radial peripapillary capillaries.
Translational relevance: This study provides new insights into the composition of PHOMS and their effects on peripapillary structures and capillaries.
期刊介绍：
Translational Vision Science & Technology (TVST), an official journal of the Association for Research in Vision and Ophthalmology (ARVO), an international organization whose purpose is to advance research worldwide into understanding the visual system and preventing, treating and curing its disorders, is an online, open access, peer-reviewed journal emphasizing multidisciplinary research that bridges the gap between basic research and clinical care. A highly qualified and diverse group of Associate Editors and Editorial Board Members is led by Editor-in-Chief Marco Zarbin, MD, PhD, FARVO.
The journal covers a broad spectrum of work, including but not limited to:
Applications of stem cell technology for regenerative medicine,
Development of new animal models of human diseases,
Tissue bioengineering,
Chemical engineering to improve virus-based gene delivery,
Nanotechnology for drug delivery,
Design and synthesis of artificial extracellular matrices,
Development of a true microsurgical operating environment,
Refining data analysis algorithms to improve in vivo imaging technology,
Results of Phase 1 clinical trials,
Reverse translational ("bedside to bench") research.
TVST seeks manuscripts from scientists and clinicians with diverse backgrounds ranging from basic chemistry to ophthalmic surgery that will advance or change the way we understand and/or treat vision-threatening diseases. TVST encourages the use of color, multimedia, hyperlinks, program code and other digital enhancements.
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