Plasma Profiles of Neuroglial Injury Biomarkers after Ischemic Stroke.

IF 4.3 2区医学 Q1 CLINICAL NEUROLOGY

Translational Stroke Research Pub Date : 2025-09-03 DOI:10.1007/s12975-025-01380-y

Karl Sjölin, Björn Röyter, Bianka Forgo, Julia Aulin, Kim Kultima, Johan Lindbäck, Jakob O Ström, Joachim Burman

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引用次数: 0

Abstract

Objective: To determine the temporal profiles of glial fibrillary acidic protein (GFAP), neurofilament light (NFL), total tau (t-tau), and ubiquitin carboxy-terminal hydrolase L1 (UCHL1) in plasma the first week after acute ischemic stroke, and identify the optimal time points for assessing infarct volume by these biomarkers.

Patients & methods: In this cohort study, biomarker plasma concentrations were determined daily over the first week and at 90 days after symptom onset in patients with acute ischemic stroke. A brain MRI was performed on day three. Temporal variations in biomarker levels were analyzed using linear mixed-effects models, and optimal time points for infarct volume correlation were identified with continuous Pearson analysis.

Results: 38 patients with a median age of 78 (IQR 72-86) and mean infarct volume of 5.5 (IQR 1.6-17) cm³ were included. We identified three distinct temporal patterns: (1) a parabolic trajectory of GFAP, reaching zenith after three days, (2) a consistent increase in NFL throughout the week, and (3) an initial surge in t-tau and UCHL1 levels, stabilizing by day three. The optimal time point for infarct volume correlation occurred at 119 h for GFAP (r = 0.94, 95% CI: [0.84-0.98]), 144 h for NFL (r = 0.78, [0.47, 0.92]), 122 h for t-tau (r = 0.82, [0.56, 0.93]) and 113 h for UCHL1 (r = 0.83, [0.60, 0.93]).

Interpretation: This high-resolution serial sampling of plasma GFAP, NFL, t-tau, and UCHL1 the first week after acute ischemic stroke identified three distinct temporal profiles. These biomarkers provided the most accurate infarct volume assessment 4-6 days after symptom onset.

Clinicaltrials: gov NCT03812666 (registration date 2019-01-23).

查看原文本刊更多论文

缺血性脑卒中后神经胶质损伤生物标志物的血浆谱。

目的：测定急性缺血性脑卒中后第一周血浆中胶质纤维酸性蛋白（GFAP）、神经丝光（NFL）、总tau蛋白（t-tau）和泛素羧基末端水解酶L1 （UCHL1）的时间谱，并确定用这些生物标志物评估梗死体积的最佳时间点。患者和方法：在这项队列研究中，在急性缺血性卒中患者症状出现后的第一周和90天，每天检测生物标志物血浆浓度。第三天进行了脑部核磁共振检查。使用线性混合效应模型分析生物标志物水平的时间变化，并通过连续Pearson分析确定梗死体积相关的最佳时间点。结果：纳入38例患者，中位年龄78岁（IQR 72-86），平均梗死体积5.5 (IQR 1.6-17) cm3。我们确定了三种不同的时间模式：(1)GFAP呈抛物线轨迹，在三天后达到顶峰；(2)NFL在整个星期内持续增加；(3)t-tau和UCHL1水平最初激增，在第三天稳定下来。梗死体积相关性的最佳时间点为GFAP的119小时（r = 0.94, 95% CI: [0.84-0.98]）， NFL的144小时（r = 0.78, [0.47, 0.92]）， t-tau的122小时（r = 0.82,[0.56, 0.93]）和UCHL1的113小时（r = 0.83,[0.60, 0.93]）。解释：急性缺血性卒中后第一周血浆GFAP、NFL、t-tau和UCHL1的高分辨率连续采样确定了三种不同的时间谱。这些生物标志物在症状出现后4-6天提供了最准确的梗死体积评估。Clinicaltrials: gov NCT03812666（注册日期2019-01-23）。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Translational Stroke Research CLINICAL NEUROLOGY-NEUROSCIENCES

CiteScore

13.80

自引率

4.30%

发文量

130

审稿时长

6-12 weeks

期刊介绍： Translational Stroke Research covers basic, translational, and clinical studies. The Journal emphasizes novel approaches to help both to understand clinical phenomenon through basic science tools, and to translate basic science discoveries into the development of new strategies for the prevention, assessment, treatment, and enhancement of central nervous system repair after stroke and other forms of neurotrauma. Translational Stroke Research focuses on translational research and is relevant to both basic scientists and physicians, including but not restricted to neuroscientists, vascular biologists, neurologists, neuroimagers, and neurosurgeons.