Factors Influencing the Effectiveness of Botulinum Toxin Therapy in Bruxism Management.

IF 4 3区医学 Q2 FOOD SCIENCE & TECHNOLOGY

Toxins Pub Date : 2025-07-31 DOI:10.3390/toxins17080384

Azusa Furuhata, Kazuya Yoshida, Shiroh Isono

{"title":"Factors Influencing the Effectiveness of Botulinum Toxin Therapy in Bruxism Management.","authors":"Azusa Furuhata, Kazuya Yoshida, Shiroh Isono","doi":"10.3390/toxins17080384","DOIUrl":null,"url":null,"abstract":"A total of 304 patients with bruxism (206 women, 98 men; mean age: 52.5 years) received 25 units of botulinum toxin injected into the bilateral masseter muscles; the changes in various clinical symptoms and their contributing factors were analyzed 2 months after treatment. The mean masseter muscle electromyographic amplitude (189 μV) and maximal bite force (618.4 N) significantly decreased after botulinum toxin therapy compared to that at baseline (55.4 μV, 527.3 N, respectively; p < 0.001). Maximal mouth opening (44 mm), sleep quality (visual analog scale: 5.3), shoulder and neck stiffness (6.7), and headache (5.4) significantly improved after the injection (47.3 mm, 6.6, 4.7, and 2.6, respectively; p < 0.001). Multivariate analysis revealed that the mean masseter electromyographic amplitude reduction rate was significantly affected by age, sex, and baseline amplitude (all p < 0.001); the maximal bite force reduction rate was influenced by age (p < 0.001), sex (p = 0.007), and baseline bite force (p = 0.008). Age, sex, and muscle activity may affect the therapeutic effects. A more effective outcome for bruxism can be achieved using a tailored approach involving dose adjustment, thereby preventing the side effects attributed to excessive dosage.","PeriodicalId":23119,"journal":{"name":"Toxins","volume":"17 8","pages":""},"PeriodicalIF":4.0000,"publicationDate":"2025-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12389857/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Toxins","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.3390/toxins17080384","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"FOOD SCIENCE & TECHNOLOGY","Score":null,"Total":0}

引用次数: 0

Abstract

A total of 304 patients with bruxism (206 women, 98 men; mean age: 52.5 years) received 25 units of botulinum toxin injected into the bilateral masseter muscles; the changes in various clinical symptoms and their contributing factors were analyzed 2 months after treatment. The mean masseter muscle electromyographic amplitude (189 μV) and maximal bite force (618.4 N) significantly decreased after botulinum toxin therapy compared to that at baseline (55.4 μV, 527.3 N, respectively; p < 0.001). Maximal mouth opening (44 mm), sleep quality (visual analog scale: 5.3), shoulder and neck stiffness (6.7), and headache (5.4) significantly improved after the injection (47.3 mm, 6.6, 4.7, and 2.6, respectively; p < 0.001). Multivariate analysis revealed that the mean masseter electromyographic amplitude reduction rate was significantly affected by age, sex, and baseline amplitude (all p < 0.001); the maximal bite force reduction rate was influenced by age (p < 0.001), sex (p = 0.007), and baseline bite force (p = 0.008). Age, sex, and muscle activity may affect the therapeutic effects. A more effective outcome for bruxism can be achieved using a tailored approach involving dose adjustment, thereby preventing the side effects attributed to excessive dosage.

Abstract Image

查看原文本刊更多论文

影响磨牙症肉毒毒素治疗效果的因素。

304例磨牙患者（女性206例，男性98例，平均年龄52.5岁）接受双侧咬肌注射肉毒杆菌毒素25单位；分析治疗2个月后各项临床症状的变化及其影响因素。肉毒杆菌毒素治疗后，咬肌平均肌电波幅（189 μV）和最大咬合力（618.4 N）较治疗前（55.4 μV、527.3 N）显著降低，p < 0.001。注射后最大开口（44 mm）、睡眠质量（视觉模拟量表：5.3）、肩颈僵硬度（6.7）和头痛（5.4）显著改善（分别为47.3 mm、6.6、4.7和2.6;p < 0.001）。多变量分析显示，平均咬肌肌电振幅降低率受年龄、性别和基线振幅的显著影响（均p < 0.001）；最大咬合力降低率受年龄（p < 0.001）、性别（p = 0.007）和基线咬合力（p = 0.008）的影响。年龄、性别和肌肉活动可能影响治疗效果。一个更有效的结果磨牙可以实现使用量身定制的方法，包括剂量调整，从而防止副作用归因于过量的剂量。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Toxins TOXICOLOGY-

CiteScore

7.50

自引率

16.70%

发文量

765

审稿时长

16.24 days

期刊介绍： Toxins (ISSN 2072-6651) is an international, peer-reviewed open access journal which provides an advanced forum for studies related to toxins and toxinology. It publishes reviews, regular research papers and short communications. Our aim is to encourage scientists to publish their experimental and theoretical results in as much detail as possible. There is no restriction on the length of the papers. The full experimental details must be provided so that the results can be reproduced.