{"title":"Peptides as Master Keys to Skin Aging.","authors":"Qianqian Zhang, Zijian Liu, Peng Shu, Ligang Jiang, Wenfeng Ding","doi":"10.1159/000547734","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Understanding skin aging and developing effective interventions represent fundamental challenges in dermatology. Key mechanisms driving this process include complex interactions among cellular senescence, extracellular matrix remodeling, oxidative stress, and inflammatory networks.</p><p><strong>Summary: </strong>Recent advances have catalyzed the development of innovative peptide-based therapeutic strategies for skin aging. These include environment-responsive peptides, biomimetic peptides, and advanced nano-delivery systems. The integration of chronobiology and multi-omics analysis further supports the evolution of these approaches.</p><p><strong>Key messages: </strong>We envision a new era of personalized solutions for skin aging, driven by the convergence of molecular understanding, delivery innovations, and precision medicine. This paradigm shift holds transformative potential not only for dermatology but also for broader aspects of human aging and health.</p>","PeriodicalId":21748,"journal":{"name":"Skin Pharmacology and Physiology","volume":" ","pages":"1-15"},"PeriodicalIF":3.2000,"publicationDate":"2025-08-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Skin Pharmacology and Physiology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1159/000547734","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"DERMATOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Background: Understanding skin aging and developing effective interventions represent fundamental challenges in dermatology. Key mechanisms driving this process include complex interactions among cellular senescence, extracellular matrix remodeling, oxidative stress, and inflammatory networks.
Summary: Recent advances have catalyzed the development of innovative peptide-based therapeutic strategies for skin aging. These include environment-responsive peptides, biomimetic peptides, and advanced nano-delivery systems. The integration of chronobiology and multi-omics analysis further supports the evolution of these approaches.
Key messages: We envision a new era of personalized solutions for skin aging, driven by the convergence of molecular understanding, delivery innovations, and precision medicine. This paradigm shift holds transformative potential not only for dermatology but also for broader aspects of human aging and health.
期刊介绍：
In the past decade research into skin pharmacology has rapidly developed with new and promising drugs and therapeutic concepts being introduced regularly. Recently, the use of nanoparticles for drug delivery in dermatology and cosmetology has become a topic of intensive research, yielding remarkable and in part surprising results. Another topic of current research is the use of tissue tolerable plasma in wound treatment. Stimulating not only wound healing processes but also the penetration of topically applied substances into the skin, this novel technique is expected to deliver very interesting results.
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