Prevalence of antenatal syphilis remains positively associated with HIV in South African districts.

IF 2.9 3区医学 Q2 INFECTIOUS DISEASES

Sexually Transmitted Infections Pub Date : 2025-08-31 DOI:10.1136/sextrans-2025-056650

Tendesayi Kufa, Nosipho Shangase, Adrian Puren, Chris Kenyon

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引用次数: 0

Abstract

Background: Previous analyses from South Africa have found that the ecological association between the prevalence of HIV and syphilis switched from positive to negative in the wake of the HIV pandemic. This was attributed to the impact of HIV mortality on sexual network connectivity. We conducted an ecological analysis of HIV prevalence and syphilis seropositivity among all districts in South Africa in 2010 and 2022.

Methods: We used Spearman's correlation to compare the weighted prevalence of HIV and syphilis per district using South Africa's 2022 Antenatal HIV Sentinel Survey. We calculated the change in the weighted syphilis and HIV prevalence per district between 2010 and 2022.

Results: The district-level antenatal prevalence of HIV in 2022 was positively correlated with the prevalence of syphilis (Rho=0.42; p=0.0018). A comparison of the same scatter plot from 2010 revealed that the six districts with the highest HIV prevalence in 2010 had large increases in syphilis prevalence from 2010 (median 0.1%, IQR 0.0%-0.4%) to 2022 (median 5.2%, IQR 4.2-5.8%).

Conclusions: The positive association between HIV and syphilis prevalence is compatible with an increase in sexual network connectivity in the districts with the largest increases in syphilis prevalence.

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在南非各地区，产前梅毒的流行率仍然与艾滋病毒呈正相关。

背景：先前来自南非的分析发现，在艾滋病毒大流行之后，艾滋病毒流行率和梅毒之间的生态关联从阳性变为阴性。这归因于艾滋病毒死亡率对性网络连通性的影响。我们在2010年和2022年对南非所有地区的艾滋病毒流行率和梅毒血清阳性进行了生态分析。方法：我们使用Spearman相关性来比较南非2022年产前艾滋病毒哨点调查中每个地区艾滋病毒和梅毒的加权患病率。我们计算了2010年至2022年间每个地区加权梅毒和艾滋病毒患病率的变化。结果：2022年区级产前HIV患病率与梅毒患病率呈正相关（Rho=0.42; p=0.0018）。对2010年同一散点图的比较显示，2010年艾滋病毒感染率最高的6个区，梅毒患病率从2010年（中位数0.1%，IQR为0.0%-0.4%）到2022年（中位数5.2%，IQR为4.2-5.8%）大幅增加。结论：在梅毒患病率增加最多的地区，HIV和梅毒患病率之间的正相关与性网络连通性的增加是一致的。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Sexually Transmitted Infections 医学-传染病学

CiteScore

5.70

自引率

8.30%

发文量

审稿时长

4-8 weeks

期刊介绍： Sexually Transmitted Infections is the world’s longest running international journal on sexual health. It aims to keep practitioners, trainees and researchers up to date in the prevention, diagnosis and treatment of all STIs and HIV. The journal publishes original research, descriptive epidemiology, evidence-based reviews and comment on the clinical, public health, sociological and laboratory aspects of sexual health from around the world. We also publish educational articles, letters and other material of interest to readers, along with podcasts and other online material. STI provides a high quality editorial service from submission to publication.