A mathematical model of human oesophageal motility function.

IF 2.9 3区综合性期刊 Q1 MULTIDISCIPLINARY SCIENCES

Royal Society Open Science Pub Date : 2025-08-20 eCollection Date: 2025-08-01 DOI:10.1098/rsos.250491

Takashi Miura, Hiroshi Ishii, Yoshitaka Hata, Hisako Takigawa-Imamura, Kei Sugihara, Shin-Ichiro Ei, Xiaopeng Bai, Eikichi Ihara, Yoshihiro Ogawa

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Abstract

Recent advances in various observation methods revealed several unique characteristics of oesophageal peristalsis and its disorders. However, a framework for understanding the oesophageal motility pattern is lacking. Here, we propose a simple mathematical model of the human oesophageal motility function. The model comprises central nervous system signals, enteric nervous system neurons (interneurons and motoneurons) and oesophageal smooth muscles. The neural function implements excitable dynamics at the oesophageal body and toggle-switch dynamics at the lower oesophageal sphincter. The local signal transmission in enteric nervous system and 'the law of the intestine' were also incorporated. The model behaviours can be understood using mathematical analysis, and we could reproduce the physiological dynamics of the normal oesophagus-deglutitive inhibition, unidirectional pulse transmission, restoration of lower oesophageal sphincter constriction and dilatation of the anal side of the pulse. In addition, we could reproduce various pathological motility patterns described in the Chicago classification by the combinations of parameter changes, which may provide insights into the possible pathogenesis of these disorders.

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人食管运动功能的数学模型。

各种观察方法的最新进展揭示了食管蠕动及其紊乱的几个独特特征。然而，缺乏一个理解食管运动模式的框架。在这里，我们提出了一个简单的数学模型的人食管运动功能。该模型由中枢神经系统信号、肠神经系统神经元（中间神经元和运动神经元）和食管平滑肌组成。神经功能实现了食管体的兴奋动态和食管下括约肌的开关动态。肠神经系统的局部信号传递和“肠律”也被纳入其中。模型行为可以用数学分析来理解，我们可以再现正常的食道-吞咽抑制、单向脉冲传递、食管下括约肌收缩恢复和肛门侧脉冲扩张的生理动态。此外，我们可以通过参数变化的组合重现芝加哥分类中描述的各种病理性运动模式，这可能为这些疾病的可能发病机制提供见解。

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来源期刊

Royal Society Open Science Multidisciplinary-Multidisciplinary

CiteScore

6.00

自引率

0.00%

发文量

508

审稿时长

14 weeks

期刊介绍： Royal Society Open Science is a new open journal publishing high-quality original research across the entire range of science on the basis of objective peer-review. The journal covers the entire range of science and mathematics and will allow the Society to publish all the high-quality work it receives without the usual restrictions on scope, length or impact.