{"title":"Sensitivity of effective dose to changes in tissue weighting factors.","authors":"Thomas Otto","doi":"10.1007/s00411-025-01143-1","DOIUrl":null,"url":null,"abstract":"<p><p>Effective dose E is the radiological protection quantity for stochastic health effects from whole-body exposure to ionising radiation. It is defined as a weighted sum of average absorbed doses in 15 selected tissues (organs), with weighting factors for radiation effectiveness and tissue sensitivity. This paper analyses the sensitivity of effective dose E with respect to the tissue weighting factors [Formula: see text]. It shows that a change of any single weighting factor by 100% results in relative changes of effective dose by a few percent for photons above an energy of 50 keV and for neutrons. Larger variations are observed for neutrons with an energy around 1 MeV and photons with low energies. The organs close to the body surface, breast and skin, are identified as the cause for these larger variations. Absolute changes of effective dose remain small, with exception for persons predominately exposed to low-energy photon radiation.</p>","PeriodicalId":21002,"journal":{"name":"Radiation and Environmental Biophysics","volume":" ","pages":""},"PeriodicalIF":2.3000,"publicationDate":"2025-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Radiation and Environmental Biophysics","FirstCategoryId":"93","ListUrlMain":"https://doi.org/10.1007/s00411-025-01143-1","RegionNum":4,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"BIOLOGY","Score":null,"Total":0}
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Abstract
Effective dose E is the radiological protection quantity for stochastic health effects from whole-body exposure to ionising radiation. It is defined as a weighted sum of average absorbed doses in 15 selected tissues (organs), with weighting factors for radiation effectiveness and tissue sensitivity. This paper analyses the sensitivity of effective dose E with respect to the tissue weighting factors [Formula: see text]. It shows that a change of any single weighting factor by 100% results in relative changes of effective dose by a few percent for photons above an energy of 50 keV and for neutrons. Larger variations are observed for neutrons with an energy around 1 MeV and photons with low energies. The organs close to the body surface, breast and skin, are identified as the cause for these larger variations. Absolute changes of effective dose remain small, with exception for persons predominately exposed to low-energy photon radiation.
期刊介绍：
This journal is devoted to fundamental and applied issues in radiation research and biophysics. The topics may include:
Biophysics of ionizing radiation: radiation physics and chemistry, radiation dosimetry, radiobiology, radioecology, biophysical foundations of medical applications of radiation, and radiation protection.
Biological effects of radiation: experimental or theoretical work on molecular or cellular effects; relevance of biological effects for risk assessment; biological effects of medical applications of radiation; relevance of radiation for biosphere and in space; modelling of ecosystems; modelling of transport processes of substances in biotic systems.
Risk assessment: epidemiological studies of cancer and non-cancer effects; quantification of risk including exposures to radiation and confounding factors
Contributions to these topics may include theoretical-mathematical and experimental material, as well as description of new techniques relevant for the study of these issues. They can range from complex radiobiological phenomena to issues in health physics and environmental protection.
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