IDAC-BioDose, a complete biokinetic and dosimetric software tool designed for diagnostic nuclear medicine and built on the ICRP computational framework.

IF 0.7 4区环境科学与生态学 Q4 ENVIRONMENTAL SCIENCES

Radiation protection dosimetry Pub Date : 2025-08-26 DOI:10.1093/rpd/ncaf044

Martin Andersson, Richard Leggett, Keith Eckerman, Sören Mattsson

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Abstract

Internal dosimetry of diagnostic nuclear medicine requires biokinetic and anatomical models to estimate the radiation exposure from a radiopharmaceutical. Biokinetic models predict the uptake, turnover, and retention of the radionuclide in organs and tissues, while anatomical models estimate energy absorption from decay using computational phantoms. To make more accurate predictions of biokinetic transfer, the International Commission on Radiological Protection (ICRP) has introduced a new compartmental framework, based on a systemic blood model, which can be used to estimate the transfer of the administered radionuclides between organs and tissues. The ICRP Task Group 36 (TG-36) is developing the biokinetic models and dosimetric calculations for radiopharmaceuticals for the ICRP. IDAC-BioDose integrates compartmental modeling and IDAC-Dose2.2. For the biokinetic predictions, transfer rates are generated through empirical data by curve fitting. IDAC-BioDose is benchmarked with SAAMII and DCAL and is used by ICRP TG-36 to revise the biokinetics and dosimetry for ICRP Publ. 128. This comprehensive software expedites absorbed dose and effective dose assessments in the field of diagnostic nuclear medicine.

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IDAC-BioDose，一个完整的生物动力学和剂量学软件工具，设计用于诊断核医学，并建立在ICRP计算框架上。

诊断性核医学的内部剂量学需要生物动力学和解剖学模型来估计放射性药物的辐射暴露。生物动力学模型预测放射性核素在器官和组织中的吸收、转换和保留，而解剖学模型利用计算模型估计衰变中的能量吸收。为了更准确地预测生物动力学转移，国际放射防护委员会（ICRP）引入了一种基于全身血液模型的新的区室框架，可用于估计给药的放射性核素在器官和组织之间的转移。ICRP第36工作组（TG-36）正在为ICRP开发放射性药物的生物动力学模型和剂量学计算。IDAC-BioDose集成了区室建模和IDAC-Dose2.2。对于生物动力学预测，通过曲线拟合的经验数据生成传输速率。IDAC-BioDose以SAAMII和DCAL为基准，被ICRP TG-36用于修订ICRP Publ. 128的生物动力学和剂量学。这个全面的软件加速吸收剂量和有效剂量评估在诊断核医学领域。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Radiation protection dosimetry 环境科学-公共卫生、环境卫生与职业卫生

CiteScore

1.40

自引率

10.00%

发文量

223

审稿时长

6-12 weeks

期刊介绍： Radiation Protection Dosimetry covers all aspects of personal and environmental dosimetry and monitoring, for both ionising and non-ionising radiations. This includes biological aspects, physical concepts, biophysical dosimetry, external and internal personal dosimetry and monitoring, environmental and workplace monitoring, accident dosimetry, and dosimetry related to the protection of patients. Particular emphasis is placed on papers covering the fundamentals of dosimetry; units, radiation quantities and conversion factors. Papers covering archaeological dating are included only if the fundamental measurement method or technique, such as thermoluminescence, has direct application to personal dosimetry measurements. Papers covering the dosimetric aspects of radon or other naturally occurring radioactive materials and low level radiation are included. Animal experiments and ecological sample measurements are not included unless there is a significant relevant content reason.