Shawnly Khoyilar, Vidya Purushothaman, Raphael E Cuomo
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引用次数: 0
Abstract
Background: Cancer treatment is often complicated by co-occurring substance dependence such as alcohol, cannabis, opioids, amphetamines, and tobacco. The objective of this study was to analyze the association between substance use (alcohol, cannabis, opioids, amphetamines, and tobacco) and mortality among cancer patients.
Methods: This retrospective study used de-identified data from the University of California, San Diego Health on 22,763 cancer patients aged ≥ 18 years. Substance dependance post-diagnosis was identified based on clinical observations from electronic health records. Tumor staging was determined using the TNM system, with missing data imputed via biomarker-based regression. Cox proportional hazards models were computed to assess severity-adjusted associations between substance dependance, by type, and mortality.
Results: Cannabis dependence was not significantly associated with mortality. Alcohol, tobacco, opioid, and amphetamine dependence were linked to increased mortality in both unadjusted and adjusted models. Adjusting for tumor stage reduced hazard ratios for opioid and tobacco dependence, suggesting stage as a confounding factor. Alcohol and opioid dependence remained significant predictors of mortality, while findings for cannabis and amphetamine were limited by small sample sizes.
Conclusion: Alcohol and opioid dependence in cancer patients was observed to be a significant predictor of mortality after adjusting for disease severity, emphasizing the need for targeted interventions among this subpopulation.
期刊介绍：
Psycho-Oncology is concerned with the psychological, social, behavioral, and ethical aspects of cancer. This subspeciality addresses the two major psychological dimensions of cancer: the psychological responses of patients to cancer at all stages of the disease, and that of their families and caretakers; and the psychological, behavioral and social factors that may influence the disease process. Psycho-oncology is an area of multi-disciplinary interest and has boundaries with the major specialities in oncology: the clinical disciplines (surgery, medicine, pediatrics, radiotherapy), epidemiology, immunology, endocrinology, biology, pathology, bioethics, palliative care, rehabilitation medicine, clinical trials research and decision making, as well as psychiatry and psychology.
This international journal is published twelve times a year and will consider contributions to research of clinical and theoretical interest. Topics covered are wide-ranging and relate to the psychosocial aspects of cancer and AIDS-related tumors, including: epidemiology, quality of life, palliative and supportive care, psychiatry, psychology, sociology, social work, nursing and educational issues.
Special reviews are offered from time to time. There is a section reviewing recently published books. A society news section is available for the dissemination of information relating to meetings, conferences and other society-related topics. Summary proceedings of important national and international symposia falling within the aims of the journal are presented.
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