Cyst-Like Central Mucoepidermoid Carcinoma.

IF 2.9 3区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE

Oral diseases Pub Date : 2025-08-31 DOI:10.1111/odi.70077

Yige Liu, Jiannan Liu, Chunye Zhang, Jing Han

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引用次数: 0

Abstract

Objective: Cyst-like central mucoepidermoid carcinoma (CC-MEC) is a special type of MEC in the jaw and clinically like a cyst. To analyze the clinicopathological features, treatment, and prognosis of CC-MEC.

Methods: From 2018 to 2023, nine patients with CC-MEC who underwent surgery were retrospectively investigated.

Results: Six females and three males, with a mean age of 43.1 (range, 10-75) years. Six in maxilla and three in mandible. Seven patients presented with painless swelling, two with pain and nasal congestion. The imaging findings were multilocular radiolucency lesions, with clear or unclear boundaries. Pathologically, six tumors had single or multiple cystic lesions with localized solid tumor cell nests. Only three tumors showed cystic-solid lesions with typical features of MEC. Eight tumors had MAML2 break-apart. Seven patients underwent fenestration or curettage, and five followed by radical surgery due to tumor recurrence. Two patients had radical resection during their initial operations. Postoperative outcomes were available for eight patients; no deaths and recurrence.

Conclusion: CC-MEC in the jaw is prone to misdiagnosis as a jaw cyst. Final diagnosis often relies on MAML2 gene testing. Curettage has a high risk of recurrence. Complete resection leads to satisfactory outcomes.

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囊肿样中央黏液表皮样癌。

目的：囊肿样中枢性黏液表皮样癌（CC-MEC）是颌部一种特殊类型的黏液表皮样癌，临床表现与囊肿相似。目的：分析CC-MEC的临床病理特点、治疗及预后。方法：回顾性分析2018年至2023年9例手术治疗的CC-MEC患者。结果：女性6例，男性3例，平均年龄43.1岁（范围10 ~ 75岁）。6个在上颌骨，3个在下颌骨。7例出现无痛性肿胀，2例出现疼痛和鼻塞。影像学表现为多室放射性病变，边界清晰或不清。病理上，6例肿瘤有单个或多个囊性病变伴局部实体瘤细胞巢。仅有3例肿瘤表现为囊性实性病变，具有MEC的典型特征。8个肿瘤有MAML2分裂。7例患者行开窗或刮除术，5例因肿瘤复发而行根治性手术。2例患者在初次手术中行根治性切除。8例患者的术后结果可用；无死亡和复发。结论：颌骨CC-MEC易误诊为颌骨囊肿。最终诊断通常依赖于MAML2基因检测。刮除有很高的复发风险。完全切除导致满意的结果。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Oral diseases 医学-牙科与口腔外科

CiteScore

7.60

自引率

5.30%

发文量

325

审稿时长

4-8 weeks

期刊介绍： Oral Diseases is a multidisciplinary and international journal with a focus on head and neck disorders, edited by leaders in the field, Professor Giovanni Lodi (Editor-in-Chief, Milan, Italy), Professor Stefano Petti (Deputy Editor, Rome, Italy) and Associate Professor Gulshan Sunavala-Dossabhoy (Deputy Editor, Shreveport, LA, USA). The journal is pre-eminent in oral medicine. Oral Diseases specifically strives to link often-isolated areas of dentistry and medicine through broad-based scholarship that includes well-designed and controlled clinical research, analytical epidemiology, and the translation of basic science in pre-clinical studies. The journal typically publishes articles relevant to many related medical specialties including especially dermatology, gastroenterology, hematology, immunology, infectious diseases, neuropsychiatry, oncology and otolaryngology. The essential requirement is that all submitted research is hypothesis-driven, with significant positive and negative results both welcomed. Equal publication emphasis is placed on etiology, pathogenesis, diagnosis, prevention and treatment.