circRNA/miRNA Networks Regulate KLF4 in Tumor Development.

IF 3.6 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

Non-Coding RNA Pub Date : 2025-07-29 DOI:10.3390/ncrna11040056

Raffaele Frazzi, Enrico Farnetti, Davide Nicoli

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引用次数: 0

Abstract

Background/Objectives: Krüppel-like factor 4 (KLF4) emerged as an epigenetically regulated gene in a variety of settings, including cell reprogramming and malignant cell proliferation. The aim of the present manuscript is to explore the relationship described in recent years between circular RNAs, miRNAs, and KLF4. These have been shown to be involved in cancers having diverse histological origins, including some of the most prevalent and deadly tumors for the human population. Expression and protein levels of this transcription factor correlate with invasiveness and prognosis in a context- and tissue-specific fashion. Methods: The literature was obtained through two main PubMed queries. The first is "miRNA and KLF4 and cancer" and is limited to the last 5 years. The second is "circRNA and KLF4", which yielded publications between 2013 and 2024. The oncological publications were selected. Results: A number of circRNA/miRNA axes that regulate the downstream transcription factor KLF4 emerged in the last few years. circRNAs act as sponges for miRNAs and synergize with KLF4, which can function as either a tumor promoter or suppressor in different tumors. Conclusions: The axes represented by circRNA/miRNA/KLF4 emerged as a new layer of epigenetic regulation. These RNA-based modulators explain the complex regulation of this transcription factor and open the way to new therapeutic targeting possibilities.

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circRNA/miRNA网络调控KLF4在肿瘤发展中的作用

背景/目的：kr ppel样因子4 （KLF4）作为一种表观遗传调控基因在多种情况下出现，包括细胞重编程和恶性细胞增殖。本文的目的是探讨近年来环状rna、mirna和KLF4之间的关系。这些已被证明与具有不同组织学起源的癌症有关，包括人类中一些最普遍和最致命的肿瘤。该转录因子的表达和蛋白水平在特定环境和组织中与侵袭性和预后相关。方法：通过两个主要PubMed查询获得文献。第一个是“miRNA和KLF4与癌症”，仅限于最近5年。第二个是“circRNA和KLF4”，发表于2013年至2024年之间。选择肿瘤学出版物。结果：近年来出现了许多调节下游转录因子KLF4的circRNA/miRNA轴。circRNAs作为mirna的海绵，与KLF4协同作用，在不同的肿瘤中可作为肿瘤启动子或抑制子。结论：以circRNA/miRNA/KLF4为代表的轴出现了一个新的表观遗传调控层。这些基于rna的调节剂解释了这种转录因子的复杂调控，并为新的治疗靶向可能性开辟了道路。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Non-Coding RNA Biochemistry, Genetics and Molecular Biology-Genetics

CiteScore

6.70

自引率

4.70%

发文量

审稿时长

10 weeks

期刊介绍： Functional studies dealing with identification, structure-function relationships or biological activity of: small regulatory RNAs (miRNAs, siRNAs and piRNAs) associated with the RNA interference pathway small nuclear RNAs, small nucleolar and tRNAs derived small RNAs other types of small RNAs, such as those associated with splice junctions and transcription start sites long non-coding RNAs, including antisense RNAs, long ''intergenic'' RNAs, intronic RNAs and ''enhancer'' RNAs other classes of RNAs such as vault RNAs, scaRNAs, circular RNAs, 7SL RNAs, telomeric and centromeric RNAs regulatory functions of mRNAs and UTR-derived RNAs catalytic and allosteric (riboswitch) RNAs viral, transposon and repeat-derived RNAs bacterial regulatory RNAs, including CRISPR RNAS Analysis of RNA processing, RNA binding proteins, RNA signaling and RNA interaction pathways: DICER AGO, PIWI and PIWI-like proteins other classes of RNA binding and RNA transport proteins RNA interactions with chromatin-modifying complexes RNA interactions with DNA and other RNAs the role of RNA in the formation and function of specialized subnuclear organelles and other aspects of cell biology intercellular and intergenerational RNA signaling RNA processing structure-function relationships in RNA complexes RNA analyses, informatics, tools and technologies: transcriptomic analyses and technologies development of tools and technologies for RNA biology and therapeutics Translational studies involving long and short non-coding RNAs: identification of biomarkers development of new therapies involving microRNAs and other ncRNAs clinical studies involving microRNAs and other ncRNAs.