Multimodal MRI characterization of brain injury in heatstroke: integrating gray matter morphometry and advanced diffusion tractometry.

IF 1.7 4区医学 Q4 NEUROSCIENCES

Neuroreport Pub Date : 2025-10-01 Epub Date: 2025-08-21 DOI:10.1097/WNR.0000000000002214

Xu Li, Zhengwei Qu, Shengyan Miao, Wenzheng Zhang, Wen Li, Xueyan Zhang, Jun Li

{"title":"Multimodal MRI characterization of brain injury in heatstroke: integrating gray matter morphometry and advanced diffusion tractometry.","authors":"Xu Li, Zhengwei Qu, Shengyan Miao, Wenzheng Zhang, Wen Li, Xueyan Zhang, Jun Li","doi":"10.1097/WNR.0000000000002214","DOIUrl":null,"url":null,"abstract":"Objective: To investigate gray-white matter injury in heatstroke using multimodal MRI, and precisely localize damaged white matter segments via automated fiber quantification (AFQ) with clinical correlation.Results: Compared with the healthy control group, VBM revealed reduced volume in bilateral cerebellar anterior lobes and left fusiform gyrus. TBSS showed widespread white matter abnormalities. AFQ identified: (a) Decreased fractional anisotropy in left corticospinal tract and right inferior fronto-occipital fasciculus; (b) increased mean diffusivity in left thalamic radiation, bilateral corticospinal tracts, corpus callosum forceps minor, bilateral inferior fronto-occipital fasciculus, left inferior longitudinal fasciculus, right superior longitudinal fasciculus, and bilateral uncinate fasciculi (false discovery rate - P < 0.05). Specific nodes in the left thalamic radiation, right corticospinal tract, right inferior fronto-occipital fasciculus, left inferior longitudinal fasciculus, and left uncinate fasciculus were correlated with Glasgow Coma Scale and coagulopathy markers.Conclusion: Heatstroke involves cerebellar/cortical atrophy and segment-specific white matter damage, where AFQ-precise localization links microstructural alterations to clinical severity and coagulopathy.","PeriodicalId":19213,"journal":{"name":"Neuroreport","volume":" ","pages":"938-947"},"PeriodicalIF":1.7000,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Neuroreport","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1097/WNR.0000000000002214","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/8/21 0:00:00","PubModel":"Epub","JCR":"Q4","JCRName":"NEUROSCIENCES","Score":null,"Total":0}

引用次数: 0

Abstract

Objective: To investigate gray-white matter injury in heatstroke using multimodal MRI, and precisely localize damaged white matter segments via automated fiber quantification (AFQ) with clinical correlation.

Results: Compared with the healthy control group, VBM revealed reduced volume in bilateral cerebellar anterior lobes and left fusiform gyrus. TBSS showed widespread white matter abnormalities. AFQ identified: (a) Decreased fractional anisotropy in left corticospinal tract and right inferior fronto-occipital fasciculus; (b) increased mean diffusivity in left thalamic radiation, bilateral corticospinal tracts, corpus callosum forceps minor, bilateral inferior fronto-occipital fasciculus, left inferior longitudinal fasciculus, right superior longitudinal fasciculus, and bilateral uncinate fasciculi (false discovery rate - P < 0.05). Specific nodes in the left thalamic radiation, right corticospinal tract, right inferior fronto-occipital fasciculus, left inferior longitudinal fasciculus, and left uncinate fasciculus were correlated with Glasgow Coma Scale and coagulopathy markers.

Conclusion: Heatstroke involves cerebellar/cortical atrophy and segment-specific white matter damage, where AFQ-precise localization links microstructural alterations to clinical severity and coagulopathy.

查看原文本刊更多论文

中暑脑损伤的多模态MRI表征：整合灰质形态测定和高级扩散束测法。

目的：利用多模态MRI研究中暑灰质-白质损伤，并利用具有临床相关性的自动纤维定量（AFQ）技术精确定位受损白质区段。结果：与健康对照组相比，VBM显示双侧小脑前叶和左侧梭状回体积减小。TBSS显示广泛的白质异常。AFQ发现：(a)左侧皮质脊髓束和右侧额枕下束各向异性分数降低；(b)左侧丘脑辐射、双侧皮质脊髓束、小胼胝体、双侧额枕下束、左侧下纵束、右侧上纵束和双侧钩状束平均弥漫性增加（假发现率- P）。中暑涉及小脑/皮质萎缩和节段特异性白质损伤，其中afq精确定位将微结构改变与临床严重程度和凝血功能障碍联系起来。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Neuroreport 医学-神经科学

CiteScore

3.20

自引率

0.00%

发文量

150

审稿时长

1 months

期刊介绍： NeuroReport is a channel for rapid communication of new findings in neuroscience. It is a forum for the publication of short but complete reports of important studies that require very fast publication. Papers are accepted on the basis of the novelty of their finding, on their significance for neuroscience and on a clear need for rapid publication. Preliminary communications are not suitable for the Journal. Submitted articles undergo a preliminary review by the editor. Some articles may be returned to authors without further consideration. Those being considered for publication will undergo further assessment and peer-review by the editors and those invited to do so from a reviewer pool. The core interest of the Journal is on studies that cast light on how the brain (and the whole of the nervous system) works. We aim to give authors a decision on their submission within 2-5 weeks, and all accepted articles appear in the next issue to press.