{"title":"Role of the NLRP3 inflammasome in diabetes and its complications (Review).","authors":"Xinyi Jiao, Guoqing Tian","doi":"10.3892/mmr.2025.13657","DOIUrl":null,"url":null,"abstract":"<p><p>Diabetes and its complications are systemic metabolic disorders triggered by chronic hyperglycemia, with the NOD‑like receptor family pyrin domain‑containing 3 (NLRP3) inflammasome carrying out a central role in disease progression. Activation of the NLRP3 inflammasome is involved not only in the onset of diabetes but also in its complications, including cardiovascular disease, nephropathy and retinopathy. The present review outlines the core mechanisms of the NLRP3 inflammasome and its specific contributions to diabetes and associated conditions. Additionally, emerging therapeutic strategies that target the NLRP3 inflammasome were explored, offering novel insights into the management of diabetes and its associated complications.</p>","PeriodicalId":18818,"journal":{"name":"Molecular medicine reports","volume":"32 5","pages":""},"PeriodicalIF":3.5000,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12395217/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Molecular medicine reports","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.3892/mmr.2025.13657","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/8/24 0:00:00","PubModel":"Epub","JCR":"Q2","JCRName":"MEDICINE, RESEARCH & EXPERIMENTAL","Score":null,"Total":0}
引用次数: 0
Abstract
Diabetes and its complications are systemic metabolic disorders triggered by chronic hyperglycemia, with the NOD‑like receptor family pyrin domain‑containing 3 (NLRP3) inflammasome carrying out a central role in disease progression. Activation of the NLRP3 inflammasome is involved not only in the onset of diabetes but also in its complications, including cardiovascular disease, nephropathy and retinopathy. The present review outlines the core mechanisms of the NLRP3 inflammasome and its specific contributions to diabetes and associated conditions. Additionally, emerging therapeutic strategies that target the NLRP3 inflammasome were explored, offering novel insights into the management of diabetes and its associated complications.
期刊介绍：
Molecular Medicine Reports is a monthly, peer-reviewed journal available in print and online, that includes studies devoted to molecular medicine, underscoring aspects including pharmacology, pathology, genetics, neurosciences, infectious diseases, molecular cardiology and molecular surgery. In vitro and in vivo studies of experimental model systems pertaining to the mechanisms of a variety of diseases offer researchers the necessary tools and knowledge with which to aid the diagnosis and treatment of human diseases.
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