Tailoring Image Contrast for Cellular Magnetic Resonance Imaging using Gadolinium Chelates and Superparamagnetic Iron Oxide Particles.

IF 2.5 4区医学 Q2 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING

Molecular Imaging and Biology Pub Date : 2025-08-21 DOI:10.1007/s11307-025-02044-x

Young Beom Kim

{"title":"Tailoring Image Contrast for Cellular Magnetic Resonance Imaging using Gadolinium Chelates and Superparamagnetic Iron Oxide Particles.","authors":"Young Beom Kim","doi":"10.1007/s11307-025-02044-x","DOIUrl":null,"url":null,"abstract":"To investigate magnetic relaxation properties of the tailored contrast using paramagnetic gadolinium (Gd) chelates and superparamagnetic iron oxide particles (SPIOs) for cellular magnetic resonance imaging. The study included three different exposed environments with two different characteristic contrast agents which used gadodiamide (Omniscan; Gd-DTPA-BMA) and ferumoxide (Feridex; SPIO) in C6 brain cancer cells. Based on the minimal mutual interaction between these two agents in vitro, we examined the possibility of using mixture of cells that are separately labeled with two contrast agents or using concurrently labeled cells with different concentrations of the two contrast agents. In order to characterize the MR relaxation properties, aqueous solutions containing various concentrations of the two contrast agents were prepared as well as Ficoll solution suspensions containing labeled cells by different labeling schemes and subsequently investigated R1 and R2 relaxation rates. The tailored contrast can be created by concurrent labeling of the two contrast agents as well as combining separately labeled cells with the two contrast agents. The proposed method would be applied to generate tailored contrast for efficient detection of magnetically-labeled cells in molecular imaging and cell-based therapy.","PeriodicalId":18760,"journal":{"name":"Molecular Imaging and Biology","volume":" ","pages":""},"PeriodicalIF":2.5000,"publicationDate":"2025-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Molecular Imaging and Biology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1007/s11307-025-02044-x","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING","Score":null,"Total":0}

引用次数: 0

Abstract

To investigate magnetic relaxation properties of the tailored contrast using paramagnetic gadolinium (Gd) chelates and superparamagnetic iron oxide particles (SPIOs) for cellular magnetic resonance imaging. The study included three different exposed environments with two different characteristic contrast agents which used gadodiamide (Omniscan; Gd-DTPA-BMA) and ferumoxide (Feridex; SPIO) in C6 brain cancer cells. Based on the minimal mutual interaction between these two agents in vitro, we examined the possibility of using mixture of cells that are separately labeled with two contrast agents or using concurrently labeled cells with different concentrations of the two contrast agents. In order to characterize the MR relaxation properties, aqueous solutions containing various concentrations of the two contrast agents were prepared as well as Ficoll solution suspensions containing labeled cells by different labeling schemes and subsequently investigated R₁ and R₂ relaxation rates. The tailored contrast can be created by concurrent labeling of the two contrast agents as well as combining separately labeled cells with the two contrast agents. The proposed method would be applied to generate tailored contrast for efficient detection of magnetically-labeled cells in molecular imaging and cell-based therapy.

查看原文本刊更多论文

使用钆螯合物和超顺磁性氧化铁颗粒定制细胞磁共振成像图像对比度。

研究顺磁性钆（Gd）螯合物和超顺磁性氧化铁颗粒（SPIOs）在细胞磁共振成像中的磁弛豫特性。该研究包括三种不同的暴露环境，两种不同的特征对比剂在C6脑癌细胞中使用gadodiamide （Omniscan; Gd-DTPA-BMA）和ferumooxide （Feridex； SPIO）。基于这两种造影剂在体外的最小相互作用，我们研究了使用分别用两种造影剂标记的细胞混合物或同时使用两种不同浓度造影剂标记的细胞的可能性。为了表征MR弛豫特性，制备了含有不同浓度的两种造影剂的水溶液，以及含有不同标记方案的标记细胞的Ficoll溶液悬浮液，随后研究了R1和R2弛豫速率。通过同时标记两种造影剂以及将分别标记的细胞与两种造影剂结合，可以创建定制的造影剂。所提出的方法将用于产生量身定制的造影剂，以便在分子成像和细胞基础治疗中有效检测磁标记细胞。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Molecular Imaging and Biology 医学-核医学

CiteScore

6.90

自引率

3.20%

发文量

审稿时长

3 months

期刊介绍： Molecular Imaging and Biology (MIB) invites original contributions (research articles, review articles, commentaries, etc.) on the utilization of molecular imaging (i.e., nuclear imaging, optical imaging, autoradiography and pathology, MRI, MPI, ultrasound imaging, radiomics/genomics etc.) to investigate questions related to biology and health. The objective of MIB is to provide a forum to the discovery of molecular mechanisms of disease through the use of imaging techniques. We aim to investigate the biological nature of disease in patients and establish new molecular imaging diagnostic and therapy procedures. Some areas that are covered are: Preclinical and clinical imaging of macromolecular targets (e.g., genes, receptors, enzymes) involved in significant biological processes. The design, characterization, and study of new molecular imaging probes and contrast agents for the functional interrogation of macromolecular targets. Development and evaluation of imaging systems including instrumentation, image reconstruction algorithms, image analysis, and display. Development of molecular assay approaches leading to quantification of the biological information obtained in molecular imaging. Study of in vivo animal models of disease for the development of new molecular diagnostics and therapeutics. Extension of in vitro and in vivo discoveries using disease models, into well designed clinical research investigations. Clinical molecular imaging involving clinical investigations, clinical trials and medical management or cost-effectiveness studies.