Decoding blood fatty acids in Crimean-Congo hemorrhagic fever.

IF 3.3 3区医学 Q2 ENDOCRINOLOGY & METABOLISM

Metabolomics Pub Date : 2025-08-29 DOI:10.1007/s11306-025-02327-y

Serkan Bolat, Seyit Ali Büyüktuna, Serra İlayda Yerlitaş, Hayrettin Yavuz, Gözde Ertürk Zararsız, Meltem Kurt Yenihan, Merve Gülşah Lafçı, Ertuğrul Keskin, Yasemin Çakır Kıymaz, Gökmen Zararsız, Halef Okan Doğan

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引用次数: 0

Abstract

Introduction: Fatty acids (FAs) are essential for cellular structure, metabolism, and inflammatory regulation. This study investigated FA profiles in Crimean-Congo hemorrhagic fever (CCHF), a severe viral illness with high mortality rates, to explore their potential as disease progression and severity biomarkers.

Methods: 190 participants were included in the study, comprising 115 CCHF-positive patients, 30 CCHF-negative patients, and 45 healthy controls. FA concentrations were analyzed via gas chromatography‒mass spectrometry (GC-MS).

Results: Statistically significant differences in specific FA levels were observed between the study groups. Compared with mild and moderate cases, severe cases showed distinctive FA profiles. Notably, higher omega-6/omega-3 ratios and linoleic acid to dihomo-γ-linolenic acid (LA/DGLA) ratios are associated with severe disease outcomes and poor prognosis and are correlated with inflammatory markers such as IL-6 and D-dimer. Pathway analysis was performed to identify disruptions in fatty acid biosynthesis and metabolism. Additionally, Cox regression analyses were conducted to determine key fatty acids associated with prognosis. Regression analyses identified several key fatty acids influencing prognosis, including myristic acid, phytanic acid, linoleic acid, gamma-linolenic acid, alpha-linolenic acid, oleic acid, behenic acid, cerotic acid, linoleic acid DGLA, omega-6 fatty acids, omega-9 fatty acids, and the omega-6/omega-3 ratio. Pathway analysis revealed that the disruptions in the most affected pathways were the biosynthesis of unsaturated fatty acids, α-linolenic acid metabolism, elongation, degradation, arachidonic acid metabolism, and fatty acid biosynthesis in CCHF pathogenesis.

Conclusion: This study highlights significant alterations in fatty acid metabolism and laboratory markers in CCHF. These findings provide insights into the pathophysiology of this disease and may guide future research on targeted therapeutic strategies.

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破译克里米亚-刚果出血热的血液脂肪酸。

脂肪酸（FAs）是细胞结构、代谢和炎症调节所必需的。本研究调查了克里米亚-刚果出血热（CCHF）的FA谱，以探索其作为疾病进展和严重程度生物标志物的潜力，CCHF是一种高死亡率的严重病毒性疾病。方法：190名参与者纳入研究，包括115名cchf阳性患者，30名cchf阴性患者和45名健康对照。通过气相色谱-质谱（GC-MS）分析FA浓度。结果：研究组间特异性FA水平差异有统计学意义。与轻度和中度病例相比，重度病例表现出明显的FA特征。值得注意的是，较高的omega-6/omega-3比率和亚油酸与二homo-γ-亚麻酸（LA/DGLA）比率与严重的疾病结局和不良预后相关，并与IL-6和d -二聚体等炎症标志物相关。通路分析是为了确定脂肪酸生物合成和代谢的中断。此外，进行Cox回归分析以确定与预后相关的关键脂肪酸。回归分析确定了影响预后的几种关键脂肪酸，包括肉豆蔻酸、植酸、亚油酸、-亚麻酸、-亚麻酸、油酸、behenic酸、cerotic酸、亚油酸DGLA、omega-6脂肪酸、omega-9脂肪酸和omega-6/omega-3比值。通路分析显示，在CCHF发病机制中，受影响最大的通路是不饱和脂肪酸的生物合成、α-亚麻酸代谢、延伸、降解、花生四烯酸代谢和脂肪酸的生物合成。结论：本研究强调了CCHF脂肪酸代谢和实验室标志物的显著改变。这些发现为该疾病的病理生理学提供了见解，并可能指导未来针对性治疗策略的研究。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Metabolomics 医学-内分泌学与代谢

CiteScore

6.60

自引率

2.80%

发文量

审稿时长

2 months

期刊介绍： Metabolomics publishes current research regarding the development of technology platforms for metabolomics. This includes, but is not limited to: metabolomic applications within man, including pre-clinical and clinical pharmacometabolomics for precision medicine metabolic profiling and fingerprinting metabolite target analysis metabolomic applications within animals, plants and microbes transcriptomics and proteomics in systems biology Metabolomics is an indispensable platform for researchers using new post-genomics approaches, to discover networks and interactions between metabolites, pharmaceuticals, SNPs, proteins and more. Its articles go beyond the genome and metabolome, by including original clinical study material together with big data from new emerging technologies.