Immune profiling in oncology: bridging the gap between technology and treatment.

IF 3.5 4区 医学 Q2 ONCOLOGY
Nanthini Ravi, Gee Jun Tye, Satvinder Singh Dhaliwal, Muhamad Yusri Musa, Matthew Tze Jian Wong, Ngit Shin Lai
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引用次数: 0

Abstract

Immune profiling has become a transformative tool in oncology, offering comprehensive information on tumor immune interactions and facilitating precision medicine. Recent advances such as mass cytometry (CyTOF), single-cell RNA sequencing (scRNA-seq), spatial transcriptomics, and liquid biopsy have greatly enhanced our ability to characterize immune heterogeneity and predict treatment responses. These innovations support the identification of new biomarkers, therapeutic targets, and resistance mechanisms, refining patient stratification and clinical results. Additionally, artificial intelligence (AI) driven models are now being employed to integrate multi-omics datasets and create predictive insights, thereby linking the gap between research and clinical decision-making. This review studies the evolution of immune profiling technologies, their integration into real-world oncology practice, and the associated technical and analytical challenges, including sample variability, data harmonization, and multi-omics integration. Although challenges such as cost, throughput, and standardization persist, the merging of advanced technologies, bioinformatics, and clinical frameworks promises to reshape cancer diagnosis, therapy selection, and disease monitoring through personalized and data-driven strategies.

Abstract Image

肿瘤学中的免疫分析:弥合技术与治疗之间的差距。
免疫谱分析已成为肿瘤学的一种变革性工具,提供肿瘤免疫相互作用的全面信息,促进精准医学。最近的进展,如细胞计数(CyTOF)、单细胞RNA测序(scRNA-seq)、空间转录组学和液体活检,极大地提高了我们表征免疫异质性和预测治疗反应的能力。这些创新有助于鉴定新的生物标志物、治疗靶点和耐药机制,完善患者分层和临床结果。此外,人工智能(AI)驱动的模型现在被用于整合多组学数据集并创建预测性见解,从而连接研究和临床决策之间的差距。本文综述了免疫谱分析技术的发展,它们与现实世界肿瘤实践的整合,以及相关的技术和分析挑战,包括样本可变性、数据协调和多组学整合。尽管成本、产量和标准化等挑战依然存在,但先进技术、生物信息学和临床框架的融合有望通过个性化和数据驱动的策略重塑癌症诊断、治疗选择和疾病监测。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Medical Oncology
Medical Oncology 医学-肿瘤学
CiteScore
4.20
自引率
2.90%
发文量
259
审稿时长
1.4 months
期刊介绍: Medical Oncology (MO) communicates the results of clinical and experimental research in oncology and hematology, particularly experimental therapeutics within the fields of immunotherapy and chemotherapy. It also provides state-of-the-art reviews on clinical and experimental therapies. Topics covered include immunobiology, pathogenesis, and treatment of malignant tumors.
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