Qinyao Yu,Fanyu Xue,Sofia Laila Wik,Mingjun Gao,Yusuff Adebayo Adebisi,Don Eliseo Lucero-Prisno Iii,Claire Chenwen Zhong,Martin C S Wong,Junjie Huang,
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引用次数: 0
Abstract
BACKGROUND
This study aims to examine the disease burden, risk factors, and temporal trends of Major Depressive Disorder (MDD) in low- and middle-income countries (LMIC) from 1990 to 2021.
METHODS
Disability-Adjusted Life Years (DALYs) data for 135 LMIC were obtained from the 2021 Global Burden of Disease (GBD) database. To assess trends in the burden of MDD, segmented regression analysis was applied to calculate the Estimated Annual Percentage Change (EAPC). Spearman correlation analysis was conducted to examine the association between Gross National Income (GNI) and gender disparities in age-standardized DALY rates (ASDR) for MDD. We also explored how key risk factors contributed to observed disparities.
RESULTS
In 2021, LMICs accounted for 80.19% of the global burden of MDD. Age and gender disparities were significant, with DALY rates increasing markedly from adolescence and peaking around age 75. Gender disparities showed a higher burden among females, particularly in countries with higher GNI per capita. Analysis of risk factors revealed that intimate partner violence, bullying victimization, and childhood sexual assault were major contributors to the MDD burden, with notable variations across income levels and age groups. Temporal trends showed a marked increase in MDD burden across all income groups after 2019.
CONCLUSION
MDD continues to impose a significant health burden in LMIC, disproportionately affecting females, youth, and elderly populations. The significant increase in MDD burden across all income groups after 2019 likely reflects the intensifying effects of global disruptions, with the COVID-19 pandemic being a key contributing factor. Populations with the highest burden also showed greater exposure to key risk factors.
期刊介绍:
Psychotherapy and Psychosomatics is a reputable journal that has been published since 1953. Over the years, it has gained recognition for its independence, originality, and methodological rigor. The journal has been at the forefront of research in psychosomatic medicine, psychotherapy research, and psychopharmacology, and has contributed to the development of new lines of research in these areas. It is now ranked among the world's most cited journals in the field.
As the official journal of the International College of Psychosomatic Medicine and the World Federation for Psychotherapy, Psychotherapy and Psychosomatics serves as a platform for discussing current and controversial issues and showcasing innovations in assessment and treatment. It offers a unique forum for cutting-edge thinking at the intersection of medical and behavioral sciences, catering to both practicing clinicians and researchers.
The journal is indexed in various databases and platforms such as PubMed, MEDLINE, Web of Science, Science Citation Index, Social Sciences Citation Index, Science Citation Index Expanded, BIOSIS Previews, Google Scholar, Academic Search, and Health Research Premium Collection, among others.