Effect of Surgical Margins on Local Recurrence Patterns of Myxofibrosarcomas: A Retrospective Cohort Study From the Stockholm Sarcoma Centre

IF 1.9 3区医学 Q3 ONCOLOGY

Journal of Surgical Oncology Pub Date : 2025-09-03 DOI:10.1002/jso.70076

Madeleine N. Hoang, Pavlos Doumanidis, Emmy Nyqvist, Jenny Löfgren, Asle C. Hesla, Panagiotis Tsagkozis

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Abstract

Introduction

One of the most common subgroups of soft tissue sarcomas are myxofibrosarcomas (MFS), which possess an infiltrative and aggressive growth pattern with a tendency for local recurrence (LR). MFS presents significant management challenges due to difficulties in achieving satisfactory surgical margins. The present study describes the LR pattern of MFS and its association with resection margin, re-excision surgery and adjuvant radiotherapy.

Method

This is a registry study conducted at the Sarcoma Centre at Karolinska University Hospital, Stockholm. All patients who underwent surgery with curative aim for MFS in this centre between 2010 and 2023 were included.

Results

LR was documented in 17/87 patients. Surgical margin was predictive of LR but not overall patient survival. The cumulative LR incidence at 3.5 years for intralesional, marginal, and wide margins were 80%, 40% and 10% respectively. RT was not shown to confer any suppressive effect on LR. Amputation was needed in five patients for local disease control.

Conclusion

Margins are the foremost determinants of LR for MFS. Proactive surgical management should be considered when margins are marginal.

Abstract Image

查看原文本刊更多论文

手术切缘对黏液纤维肉瘤局部复发模式的影响：来自斯德哥尔摩肉瘤中心的回顾性队列研究。

简介：粘液纤维肉瘤（MFS）是软组织肉瘤最常见的亚群之一，它具有浸润性和侵袭性的生长模式，并有局部复发（LR）的倾向。由于难以获得满意的手术切缘，MFS提出了重大的管理挑战。本研究描述了MFS的LR模式及其与切除边缘、再切除手术和辅助放疗的关系。方法：这是一项在斯德哥尔摩卡罗林斯卡大学医院肉瘤中心进行的登记研究。2010年至2023年期间在该中心接受手术治疗MFS的所有患者均被纳入研究。结果：87例患者中有17例出现LR。手术切缘可预测LR，但不能预测患者总体生存率。3.5年时病灶内、边缘和宽边缘的累积LR发生率分别为80%、40%和10%。RT未显示对LR有任何抑制作用。5例患者因局部疾病控制需要截肢。结论：边缘是MFS的主要决定因素。当边缘很小时，应考虑主动手术治疗。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Surgical Oncology 医学-外科

CiteScore

4.70

自引率

4.00%

发文量

367

审稿时长

2 months

期刊介绍： The Journal of Surgical Oncology offers peer-reviewed, original papers in the field of surgical oncology and broadly related surgical sciences, including reports on experimental and laboratory studies. As an international journal, the editors encourage participation from leading surgeons around the world. The JSO is the representative journal for the World Federation of Surgical Oncology Societies. Publishing 16 issues in 2 volumes each year, the journal accepts Research Articles, in-depth Reviews of timely interest, Letters to the Editor, and invited Editorials. Guest Editors from the JSO Editorial Board oversee multiple special Seminars issues each year. These Seminars include multifaceted Reviews on a particular topic or current issue in surgical oncology, which are invited from experts in the field.