Role of immunity and inflammation in sarcopenic obesity

IF 4.9 2区医学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Journal of Nutritional Biochemistry Pub Date : 2025-08-19 DOI:10.1016/j.jnutbio.2025.110077

Yu-Cen Ma , Xiao-Ping Li , Xiao-Ye Lin , Ke-Xin Zhang , Ji-Yan Leng

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Abstract

The global aging population brings about various age-related clinical concerns, including sarcopenic obesity (SO), which poses a significant health risk for older individuals. SO is characterized by the coexistence of two phenotypes, namely, sarcopenia and obesity, and its pathogenesis is multifaceted. Current research indicates that both reduced muscle mass and excessive fat accumulation are associated with chronic low-grade inflammatory conditions. In addition, these two issues have the potential to exacerbate each other's effects. This review highlights recent advances in understanding the role of immunity and inflammation in the development of SO. Specifically, we provide a novel perspective by integrating how aging and obesity jointly contribute to SO through immune-inflammatory pathways. Furthermore, we discuss the influence of sex differences in immune responses and inflammatory processes, which may account for the variability observed in SO susceptibility and progression. Finally, we summarize current and emerging therapeutic strategies to provide potential directions for the treatment of SO.

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免疫和炎症在肌少性肥胖中的作用。

全球人口老龄化带来了各种与年龄相关的临床问题，包括肌肉减少性肥胖（SO），这对老年人构成了重大的健康风险。SO具有肌肉减少症和肥胖两种表型共存的特点，其发病机制是多方面的。目前的研究表明，肌肉量减少和脂肪堆积过多都与慢性低度炎症有关。此外，这两个问题有可能加剧彼此的影响。这篇综述强调了在了解免疫和炎症在SO发展中的作用方面的最新进展。具体来说，我们通过整合衰老和肥胖如何通过免疫炎症途径共同促进SO，提供了一个新的视角。此外，我们讨论了免疫反应和炎症过程中性别差异的影响，这可能解释了SO易感性和进展中观察到的可变性。最后，我们总结了当前和新兴的治疗策略，为SO的治疗提供了潜在的方向。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Nutritional Biochemistry 医学-生化与分子生物学

CiteScore

9.50

自引率

3.60%

发文量

237

审稿时长

68 days

期刊介绍： Devoted to advancements in nutritional sciences, The Journal of Nutritional Biochemistry presents experimental nutrition research as it relates to: biochemistry, molecular biology, toxicology, or physiology. Rigorous reviews by an international editorial board of distinguished scientists ensure publication of the most current and key research being conducted in nutrition at the cellular, animal and human level. In addition to its monthly features of critical reviews and research articles, The Journal of Nutritional Biochemistry also periodically publishes emerging issues, experimental methods, and other types of articles.