Effects of Oligonol® Supplementation on Abdominal Fat in Japanese Overweight Volunteers: A Randomized, Double-Blind, Placebo-Controlled, Parallel Group Study.

IF 1.1 4区 医学 Q4 NUTRITION & DIETETICS
Jun Takanari, Manami Misu, Kazunori Goto, Takuma Shio, Yukiko Fukuchi, Hajime Fujii, Jun Nishihira
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Abstract

Obesity is known to induce diabetes, hypertension, and dyslipidemia, and reducing obesity is important from the perspective of disease prevention. Oligonol, a standardized oligomerized-polyphenol from Litchi chinensis fruit extract, is expected to have high absorption and body fat reduction. In this study, the effects of Oligonol intake on abdominal fat were examined in overweight Japanese participants. This randomized, double-blind, placebo-controlled trial was performed including 66 overweight adult men and women (body mass index [BMI] of 25 or more and less than 30 kg/m2) who were assigned to receive a daily dose of placebo or 200 mg Oligonol (40 mg as monomers and dimers of flavanols from lychee and tea) for 12 wk. The primary endpoint was a reduction of the visceral fat area (VFA) as quantified by computed tomography scanning after continual intake of test foods for 12 wk. In addition, body weight, BMI, waist circumference, peripheral blood tests, and general urinalysis were performed. Of 66 participants (33 per group), 63 were included in the efficacy analysis (placebo n=32; Oligonol n=31). Intake of 200 mg Oligonol significantly reduced abdominal VFA compared with the placebo group. No clinically relevant adverse events related to the intake of Oligonol were observed. These results indicate that Oligonol had the abdominal visceral fat reduction effect in overweight participants.

寡糖醇®补充剂对日本超重志愿者腹部脂肪的影响:一项随机、双盲、安慰剂对照、平行组研究。
肥胖会引起糖尿病、高血压、血脂异常,从预防疾病的角度来看,减少肥胖是很重要的。寡糖醇是一种从荔枝果实提取物中提取的标准化寡聚多酚,有望具有高吸收率和减脂性。在这项研究中,研究了日本超重参与者摄入寡糖醇对腹部脂肪的影响。这项随机、双盲、安慰剂对照试验包括66名超重的成年男性和女性(体重指数[BMI]为25或以上,小于30 kg/m2),他们被分配接受每日剂量的安慰剂或200毫克寡糖醇(40毫克为荔枝和茶黄烷醇的单体和二聚体),持续12周。主要终点是在连续摄入测试食物12周后,通过计算机断层扫描量化的内脏脂肪面积(VFA)的减少。此外,还进行了体重、BMI、腰围、外周血检查和一般尿液分析。在66名参与者(每组33人)中,63人被纳入疗效分析(安慰剂n=32;寡糖醇n=31)。与安慰剂组相比,摄入200毫克寡糖醇显著减少腹部VFA。未观察到与摄入寡糖醇相关的临床相关不良事件。这些结果表明,寡糖醇在超重参与者中具有腹部内脏脂肪减少作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
1.80
自引率
6.20%
发文量
63
审稿时长
6-12 weeks
期刊介绍: The Journal of Nutritional Science and Vitaminology is an international medium publishing in English of original work in all branches of nutritional science, food science and vitaminology from any country. Manuscripts submitted for publication should be as concise as possible and must be based on the results of original research or of original interpretation of existing knowledge not previously published. Although data may have been reported, in part, in preliminary or abstract form, a full report of such research is unacceptable if it has been or will be submitted for consideration by another journal.
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