Comparison of the Efficacy of Pre-Germinated Brown Rice Extract and γ-Oryzanol against Non-Alcoholic Fatty Liver Disease and Cardiac Complications Induced by a High-Fructose/Fat Diet.
{"title":"Comparison of the Efficacy of Pre-Germinated Brown Rice Extract and γ-Oryzanol against Non-Alcoholic Fatty Liver Disease and Cardiac Complications Induced by a High-Fructose/Fat Diet.","authors":"Bin-Nan Wu, Hui-Li Lin, Huey-Jen Su, Pei-Wen Cheng, Ya-Mei Chen, Chi-Long Hao, Kuo-Ping Shen","doi":"10.3177/jnsv.71.321","DOIUrl":null,"url":null,"abstract":"<p><p>This animal experiment aimed to evaluate the efficacy of the extract of pre-germinated brown rice (EP) and γ-oryzanol on non-alcoholic fatty liver disease (NAFLD) and the cardiac complications associated with it. WKY rats were fed high-fructose water (HFW) and high-fat diet (HFD) for 4 wk to induce NAFLD. The other two groups were fed HFW and HFD, while oral administration of EP 200 μL/kg or γ-oryzanol 2 mg/kg every day for 4 wk. NAFLD was successfully induced in as evidenced by clear increases in body, hepatic and cardiac weight as well as by increases in blood pressure and heart rate, hypertriglyceridemia, hyperuricemia, higher liver function index: glutamic pyruvic transaminase (GPT), higher levels of IL-6 and TNF-α in the blood and higher levels TG in the liver. NAFLD rats also had adverse changes the protein expressions of lipid synthesis, inflammation, cardiac fibrosis and hypertrophy. However, when the NAFLD rats were simultaneously fed EP or γ-oryzanol, the development of adverse diet-induced effects, including glutamic oxaloacetic transaminase (GOT), were clearly ameliorated. Specifically, EP could reduce uric acid levels, while γ-oryzanol did not. EP, as well as γ-oryzanol, reversed the increases in levels of lipid synthesis, inflammation, cardiac fibrosis and hypertrophy. We concluded that EP effectively prevented HFW/HFD-induced NAFLD and its associated cardiac complications, which it likely achieved through an improvement of lipid homeostasis and inhibition of inflammation. We believe that EP, like γ-oryzanol, can be developed as a beneficial agent for the prevention and control of NAFLD and associated cardiac dysfunction.</p>","PeriodicalId":16624,"journal":{"name":"Journal of nutritional science and vitaminology","volume":"71 4","pages":"321-330"},"PeriodicalIF":1.1000,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of nutritional science and vitaminology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.3177/jnsv.71.321","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"NUTRITION & DIETETICS","Score":null,"Total":0}
引用次数: 0
Abstract
This animal experiment aimed to evaluate the efficacy of the extract of pre-germinated brown rice (EP) and γ-oryzanol on non-alcoholic fatty liver disease (NAFLD) and the cardiac complications associated with it. WKY rats were fed high-fructose water (HFW) and high-fat diet (HFD) for 4 wk to induce NAFLD. The other two groups were fed HFW and HFD, while oral administration of EP 200 μL/kg or γ-oryzanol 2 mg/kg every day for 4 wk. NAFLD was successfully induced in as evidenced by clear increases in body, hepatic and cardiac weight as well as by increases in blood pressure and heart rate, hypertriglyceridemia, hyperuricemia, higher liver function index: glutamic pyruvic transaminase (GPT), higher levels of IL-6 and TNF-α in the blood and higher levels TG in the liver. NAFLD rats also had adverse changes the protein expressions of lipid synthesis, inflammation, cardiac fibrosis and hypertrophy. However, when the NAFLD rats were simultaneously fed EP or γ-oryzanol, the development of adverse diet-induced effects, including glutamic oxaloacetic transaminase (GOT), were clearly ameliorated. Specifically, EP could reduce uric acid levels, while γ-oryzanol did not. EP, as well as γ-oryzanol, reversed the increases in levels of lipid synthesis, inflammation, cardiac fibrosis and hypertrophy. We concluded that EP effectively prevented HFW/HFD-induced NAFLD and its associated cardiac complications, which it likely achieved through an improvement of lipid homeostasis and inhibition of inflammation. We believe that EP, like γ-oryzanol, can be developed as a beneficial agent for the prevention and control of NAFLD and associated cardiac dysfunction.
期刊介绍:
The Journal of Nutritional Science and Vitaminology is an international medium publishing in English of original work in all branches of nutritional science, food science and vitaminology from any country.
Manuscripts submitted for publication should be as concise as possible and must be based on the results of original research or of original interpretation of existing knowledge not previously published. Although data may have been reported, in part, in preliminary or
abstract form, a full report of such research is unacceptable if it has been or will be submitted for consideration by another journal.