Feasibility and Preliminary Efficacy of Digital Cognitive Training in Parkinson's Disease with Mild Cognitive Impairment: A Pilot Study.

IF 2.8 4区医学 Q2 CLINICAL NEUROLOGY

Journal of Movement Disorders Pub Date : 2025-08-26 DOI:10.14802/jmd.25135

Dongje Lee, Hang-Rai Kim, Yu Jeong Park, Yisuh Ahn, Daeho Lee, Jungyeun Lee, Su Jin Chung, Seung Yeon Kim, Yeji Hwang, Ji Young Yun, Jin Whan Cho, Kyum-Yil Kwon, Seong-Beom Koh, Sung Hoon Kang

{"title":"Feasibility and Preliminary Efficacy of Digital Cognitive Training in Parkinson's Disease with Mild Cognitive Impairment: A Pilot Study.","authors":"Dongje Lee, Hang-Rai Kim, Yu Jeong Park, Yisuh Ahn, Daeho Lee, Jungyeun Lee, Su Jin Chung, Seung Yeon Kim, Yeji Hwang, Ji Young Yun, Jin Whan Cho, Kyum-Yil Kwon, Seong-Beom Koh, Sung Hoon Kang","doi":"10.14802/jmd.25135","DOIUrl":null,"url":null,"abstract":"Objective: Cognitive impairment is common in Parkinson's disease (PD), with few pharmacological options. We evaluated the effects of a digital cognitive training program (SUPERBRAIN), previously effective in Alzheimer's risk populations, on cognitive function in PD.Methods: Twenty-nine patients with PD and mild cognitive impairment (PD-MCI) from four clinics were randomized to intervention (n=16) or control (n=7). The intervention group completed a 12-week, home-based, tablet cognitive training program (25-30 min/day, 7 days/week). Cognitive outcomes were assessed using the Seoul Neuropsychological Screening Battery pre- and post-intervention.Results: Adherence was 79.4%. The intervention group showed significant improvements in the Seoul Verbal Learning Test (SVLT) delayed recall and controlled oral word association test, with no changes in controls. ANCOVA confirmed a greater SVLT improvement in the intervention group ((F-statistics = 7.15, P-value = 0.015, partial η² = 0.28).Conclusions: SUPERBRAIN is feasible and improves cognitive function in PD-MCI.","PeriodicalId":16372,"journal":{"name":"Journal of Movement Disorders","volume":" ","pages":""},"PeriodicalIF":2.8000,"publicationDate":"2025-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Movement Disorders","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.14802/jmd.25135","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"CLINICAL NEUROLOGY","Score":null,"Total":0}

引用次数: 0

Abstract

Objective: Cognitive impairment is common in Parkinson's disease (PD), with few pharmacological options. We evaluated the effects of a digital cognitive training program (SUPERBRAIN), previously effective in Alzheimer's risk populations, on cognitive function in PD.

Methods: Twenty-nine patients with PD and mild cognitive impairment (PD-MCI) from four clinics were randomized to intervention (n=16) or control (n=7). The intervention group completed a 12-week, home-based, tablet cognitive training program (25-30 min/day, 7 days/week). Cognitive outcomes were assessed using the Seoul Neuropsychological Screening Battery pre- and post-intervention.

Results: Adherence was 79.4%. The intervention group showed significant improvements in the Seoul Verbal Learning Test (SVLT) delayed recall and controlled oral word association test, with no changes in controls. ANCOVA confirmed a greater SVLT improvement in the intervention group ((F-statistics = 7.15, P-value = 0.015, partial η² = 0.28).

Conclusions: SUPERBRAIN is feasible and improves cognitive function in PD-MCI.

查看原文本刊更多论文

数字认知训练治疗帕金森病伴轻度认知障碍的可行性及初步疗效：一项初步研究。

目的：认知障碍在帕金森病（PD）中很常见，很少有药物选择。我们评估了数字认知训练计划（SUPERBRAIN）对PD患者认知功能的影响，该计划先前在阿尔茨海默氏症风险人群中有效。方法：29例PD合并轻度认知障碍（PD- mci）患者随机分为干预组（n=16）和对照组（n=7）。干预组完成了为期12周、以家庭为基础的平板电脑认知训练计划（每天25-30分钟，每周7天）。认知结果评估使用首尔神经心理筛查电池前后干预。结果：依从性为79.4%。干预组在首尔语言学习测试（SVLT）延迟回忆和控制口语单词联想测试中有显著改善，对照组无变化。ANCOVA证实干预组有更大的SVLT改善（F-statistics = 7.15, P-value = 0.015，偏η²= 0.28）。结论：SUPERBRAIN是可行的，能改善PD-MCI患者的认知功能。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊