Aleksandra Veselinović, Jelena Kotur-Stevuljevć, Aleksandar Stojsavljević, Dragana Bojović-Jović, Aleksandra Arsić, Marija Paunović, Vesna Vučić
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引用次数: 0
Abstract
Background: Infertility remains a prevalent global reproductive challenge, significantly affecting the lives of couples worldwide. The aetiology of infertility can be affected by various factors that exhibit possible relationships with one another. The study aimed to investigate factors that can interact with and influence the pregnancy outcome in couples undergoing assisted reproductive technology procedures.
Methods: This retrospective study included 64 couples (64 men and their female partners) undergoing assisted reproductive technology procedures, having different pregnancy outcomes and lifestyle habits. Biomarkers of antioxidative and fatty acid status in the serum of both male and female partners, as well as the concentration of zinc in serum and seminal plasma of men, and their impact on assisted reproductive technology outcome were examined.
Results: We grouped the parameters using principal component analysis and identified the three most contributing factors to the pregnancy achievement - seminogram parameters in males and redox status scores in female participants; supplementation with vitamin D, magnesium, and zinc; and serum levels of omega-3 and omega-6 fatty acids.
Conclusions: The study concluded that seminogram parameters, intake of micronutrients, and levels of zinc, omega-3, and omega-6 fatty acids are contributing factors to the success of assisted reproductive technology. Further studies on a larger cohort are needed to confirm the predictive role of these factors on the success of assisted reproductive technology.
期刊介绍:
The JOURNAL OF MEDICAL BIOCHEMISTRY (J MED BIOCHEM) is the official journal of the Society of Medical Biochemists of Serbia with international peer-review. Papers are independently reviewed by at least two reviewers selected by the Editors as Blind Peer Reviews. The Journal of Medical Biochemistry is published quarterly.
The Journal publishes original scientific and specialized articles on all aspects of
clinical and medical biochemistry,
molecular medicine,
clinical hematology and coagulation,
clinical immunology and autoimmunity,
clinical microbiology,
virology,
clinical genomics and molecular biology,
genetic epidemiology,
drug measurement,
evaluation of diagnostic markers,
new reagents and laboratory equipment,
reference materials and methods,
reference values,
laboratory organization,
automation,
quality control,
clinical metrology,
all related scientific disciplines where chemistry, biochemistry, molecular biology and immunochemistry deal with the study of normal and pathologic processes in human beings.