Comparison of the effects of citicoline and vascular rehabilitation capsules on neurotrophic and inflammatory factors in patients with cerebral infarction.

IF 1.5 4区医学 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY

Journal of Medical Biochemistry Pub Date : 2025-07-04 DOI:10.5937/jomb0-55775

Dongyun Wu, Jiajun Pan, Xinhong Fang, Zhongjun Chen

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引用次数: 0

Abstract

Background: Butylphthalide (BP) is commonly used to treat vascular dementia (VD) following cerebral infarction (CI), but BP alone has limited efficacy. BP in combination with citicoline (COPC) or vascular rehabilitation capsules (VRC) is common in clinical practice, but few studies have compared the differences between these two treatment options.

Methods: Ninety-eight patients with VD after CI who were seen in our hospital from April 2020 to June 2022 were selected as the study population. Among them, 52 patients received BP combined with COPC (BP+COPC group), while the rest 46 received BP combined with VRC (BP+VRC group). Fasting venous blood was drawn from the patients before and after treatment. The levels of neurotrophic factor [nerve growth factor (NGF), neuron-specific enolase (NSE), brain-derived neurotrophic factor (BDNF)], oxidative stress [superoxide dismutase (SOD), malondialdehyde (MDA)], and inflammatory factors [Tumor necrosis factor-a (TNF-a), Interleukin-1 (IL-1b), C-reactive protein (CRP)] were measured. Cognitive and neurological improvements were assessed using the Loewenstein Occupational Therapy Cognitive Assessment (LOTCA) and the National Institute of Health Stroke Scale (NIHSS). In addition, the patient's cerebral hemodynamics were examined by CT.

Results: After treatment, LOTCA increased in both groups and was higher in the BP+COPC group than in the BP+VRC group (P<0.05), while NIHSS decreased in the BP+COPC group than in the BP+VRC group (P<0.05). NSE, MDA, IL-1 , CRP, and TNF-a decreased in both groups after treatment, while NGF, BDNF, and SOD increased, again with more significant changes in the BP+COPC group (P<0.05). In addition, cerebral hemodynamics was more favourable in the BP+COPC group than in the BP+VRC group (P<0.05).

Conclusions: BP combined with COPC has superior improvement in neurologic function in patients with VD after CI.

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胞胆碱与血管康复胶囊对脑梗死患者神经营养及炎症因子影响的比较。

背景：丁苯酞（Butylphthalide， BP）常用于治疗脑梗死（CI）后血管性痴呆（vascular dementia， VD），但单独使用BP的疗效有限。BP联合胞胆碱（COPC）或血管康复胶囊（VRC）在临床实践中很常见，但很少有研究比较这两种治疗方案的差异。方法：选择2020年4月至2022年6月在我院就诊的CI后VD患者98例作为研究人群。其中52例患者接受BP联合COPC治疗（BP+COPC组），46例患者接受BP联合VRC治疗（BP+VRC组）。分别于治疗前后抽取空腹静脉血。测定神经营养因子[神经生长因子（NGF）、神经元特异性烯醇化酶（NSE）、脑源性神经营养因子（BDNF）]、氧化应激[超氧化物歧化酶（SOD）、丙二醛（MDA）]、炎症因子[肿瘤坏死因子-a （TNF-a）、白细胞介素-1 （IL-1b）、c反应蛋白（CRP）]水平。使用Loewenstein职业治疗认知评估（LOTCA）和美国国立卫生研究院卒中量表（NIHSS）评估认知和神经学改善。CT检查患者脑血流动力学。结果：治疗后，两组患者的LOTCA均升高，且BP+COPC组的LOTCA高于BP+VRC组(结论：BP联合COPC对CI后VD患者神经功能的改善更明显。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Medical Biochemistry BIOCHEMISTRY & MOLECULAR BIOLOGY-

CiteScore

3.00

自引率

12.00%

发文量

审稿时长

>12 weeks

期刊介绍： The JOURNAL OF MEDICAL BIOCHEMISTRY (J MED BIOCHEM) is the official journal of the Society of Medical Biochemists of Serbia with international peer-review. Papers are independently reviewed by at least two reviewers selected by the Editors as Blind Peer Reviews. The Journal of Medical Biochemistry is published quarterly. The Journal publishes original scientific and specialized articles on all aspects of clinical and medical biochemistry, molecular medicine, clinical hematology and coagulation, clinical immunology and autoimmunity, clinical microbiology, virology, clinical genomics and molecular biology, genetic epidemiology, drug measurement, evaluation of diagnostic markers, new reagents and laboratory equipment, reference materials and methods, reference values, laboratory organization, automation, quality control, clinical metrology, all related scientific disciplines where chemistry, biochemistry, molecular biology and immunochemistry deal with the study of normal and pathologic processes in human beings.