Biocompatible Hybrid Surface Layers on Porous Magnesium Structures Fabricated by Spark Sintering.

IF 5.2 3区医学 Q1 ENGINEERING, BIOMEDICAL

Journal of Functional Biomaterials Pub Date : 2025-07-22 DOI:10.3390/jfb16080269

Konstantine V Nadaraia, Anastasia A Golysheva, Evgeniy A Belov, Dmitry A Lyapin, Mariia S Gerasimenko, Maria A Nadaraia, Arina I Pleshkova, Igor M Imshinetskiy, Oleg O Shichalin, Anton A Belov, Eugeniy K Papynov, Sergey S Atarshchikov, Dmitry V Mashtalyar

{"title":"Biocompatible Hybrid Surface Layers on Porous Magnesium Structures Fabricated by Spark Sintering.","authors":"Konstantine V Nadaraia, Anastasia A Golysheva, Evgeniy A Belov, Dmitry A Lyapin, Mariia S Gerasimenko, Maria A Nadaraia, Arina I Pleshkova, Igor M Imshinetskiy, Oleg O Shichalin, Anton A Belov, Eugeniy K Papynov, Sergey S Atarshchikov, Dmitry V Mashtalyar","doi":"10.3390/jfb16080269","DOIUrl":null,"url":null,"abstract":"<p><p>In this study, 3D Mg scaffolds were obtained by the spark plasma sintering (SPS), and a calcium phosphate coating was then obtained on the samples by the plasma electrolytic oxidation. A hybrid coating with vancomycin, zoledronic acid, and menaquinone MK-7 was formed to improve biocompatibility. The mechanical properties of the formed specimens were studied. According to XRD, XRF, SEM, EDS, and OSP studies obtained scaffolds have developed morphology and contain hydroxyapatite as well as bioactive substances. Formation of coatings improves the wettability of samples (contact angle decreases from 123.8 ± 3.1° to 26.9 ± 4.1°) and increases the surface roughness by more than 3 times. This makes them promising for use as a new generation of implantation materials. The results are important for the development of personalized implants with improved functional characteristics.</p>","PeriodicalId":15767,"journal":{"name":"Journal of Functional Biomaterials","volume":"16 8","pages":""},"PeriodicalIF":5.2000,"publicationDate":"2025-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12387148/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Functional Biomaterials","FirstCategoryId":"5","ListUrlMain":"https://doi.org/10.3390/jfb16080269","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"ENGINEERING, BIOMEDICAL","Score":null,"Total":0}

引用次数: 0

Abstract

In this study, 3D Mg scaffolds were obtained by the spark plasma sintering (SPS), and a calcium phosphate coating was then obtained on the samples by the plasma electrolytic oxidation. A hybrid coating with vancomycin, zoledronic acid, and menaquinone MK-7 was formed to improve biocompatibility. The mechanical properties of the formed specimens were studied. According to XRD, XRF, SEM, EDS, and OSP studies obtained scaffolds have developed morphology and contain hydroxyapatite as well as bioactive substances. Formation of coatings improves the wettability of samples (contact angle decreases from 123.8 ± 3.1° to 26.9 ± 4.1°) and increases the surface roughness by more than 3 times. This makes them promising for use as a new generation of implantation materials. The results are important for the development of personalized implants with improved functional characteristics.

查看原文本刊更多论文

火花烧结制备多孔镁结构生物相容性杂化表面层。

本研究采用火花等离子烧结（SPS）法制备了三维Mg支架，并采用等离子电解氧化法制备了一层磷酸钙涂层。万古霉素、唑来膦酸和甲基萘醌MK-7组成了一种杂化包衣，以提高生物相容性。对成形试样的力学性能进行了研究。通过XRD、XRF、SEM、EDS和OSP的研究，得到的支架形态发育，含有羟基磷灰石和生物活性物质。涂层的形成提高了样品的润湿性（接触角从123.8±3.1°降低到26.9±4.1°），表面粗糙度提高了3倍以上。这使得它们有望成为新一代植入材料。该结果对于开发具有改进功能特征的个性化植入物具有重要意义。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Journal of Functional Biomaterials Engineering-Biomedical Engineering

CiteScore

4.60

自引率

4.20%

发文量

226

审稿时长

11 weeks

期刊介绍： Journal of Functional Biomaterials (JFB, ISSN 2079-4983) is an international and interdisciplinary scientific journal that publishes regular research papers (articles), reviews and short communications about applications of materials for biomedical use. JFB covers subjects from chemistry, pharmacy, biology, physics over to engineering. The journal focuses on the preparation, performance and use of functional biomaterials in biomedical devices and their behaviour in physiological environments. Our aim is to encourage scientists to publish their results in as much detail as possible. Therefore, there is no restriction on the length of the papers. The full experimental details must be provided so that the results can be reproduced. Several topical special issues will be published. Scope: adhesion, adsorption, biocompatibility, biohybrid materials, bio-inert materials, biomaterials, biomedical devices, biomimetic materials, bone repair, cardiovascular devices, ceramics, composite materials, dental implants, dental materials, drug delivery systems, functional biopolymers, glasses, hyper branched polymers, molecularly imprinted polymers (MIPs), nanomedicine, nanoparticles, nanotechnology, natural materials, self-assembly smart materials, stimuli responsive materials, surface modification, tissue devices, tissue engineering, tissue-derived materials, urological devices.