Photothermally Responsive Biomimetic Composite Scaffolds Based on Polydopamine-Functionalized Nanoparticles/Polyurethane for Bone Repair.

IF 5.2 3区医学 Q1 ENGINEERING, BIOMEDICAL

Journal of Functional Biomaterials Pub Date : 2025-08-15 DOI:10.3390/jfb16080294

Ruqing Bai, Jiaqi Chen, Ting Zhang, Tao Chen, Xiaoying Liu, Weihu Yang, Tuck-Whye Wong, Jianwei Zhang, Li Wang

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引用次数: 0

Abstract

In this study, a shape-changeable 3D scaffold with photothermal effects was developed to address the clinical challenges of complex bone defects. The multifunctional construct was fabricated via in situ polymerization combined with a gas foaming technique, creating hierarchical porous architectures that mimic the native bone extracellular matrix. By incorporating polydopamine (PDA)-modified amorphous calcium phosphate (CA) into poly(propylene glycol) (PPG)- and poly(ԑ-caprolactone) (PCL)-based polyurethane (PU). The obtained scaffolds achieved osteoinductive potential for bone tissue engineering. The surface PDA modification of CA enabled efficient photothermal shape conversion under near-infrared (NIR) irradiation, facilitating non-invasive remote control of localized hyperthermia. The optimized scaffolds exhibited interconnected porosity (approximately 70%) with osteoconductive pore channels (200-500 μm), resulting in good osteoinduction in cell culture, and precise shape-memory recovery at physiological temperatures (~40 °C) under NIR for minimally invasive delivery. The synergistic effect of osteogenesis promotion and photothermal transition demonstrated this programmable scaffold as a promising solution for integrated minimally invasive bone repair and defect reconstruction.

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基于聚多巴胺功能化纳米颗粒/聚氨酯的光热响应仿生骨修复支架。

在这项研究中，开发了一种具有光热效应的可变形3D支架来解决复杂骨缺损的临床挑战。多功能结构是通过原位聚合结合气体发泡技术制造的，创造了模拟天然骨细胞外基质的分层多孔结构。将聚多巴胺（PDA）修饰的无定形磷酸钙（CA）掺入聚丙二醇（PPG）和聚（ԑ-己内酯）（PCL）基聚氨酯（PU）中。所得支架具有骨组织工程的骨诱导潜能。CA的表面PDA修饰可以在近红外（NIR）照射下实现有效的光热形状转换，从而实现对局部热疗的无创远程控制。优化后的支架具有与成骨孔通道（200-500 μm）相互连接的孔隙度（约70%），在细胞培养中具有良好的骨诱导性，并且在近红外下生理温度（~40°C）下具有精确的形状记忆恢复，可用于微创递送。促进成骨和光热转换的协同作用表明，这种可编程支架是一种很有前途的微创骨修复和缺损重建方案。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Functional Biomaterials Engineering-Biomedical Engineering

CiteScore

4.60

自引率

4.20%

发文量

226

审稿时长

11 weeks

期刊介绍： Journal of Functional Biomaterials (JFB, ISSN 2079-4983) is an international and interdisciplinary scientific journal that publishes regular research papers (articles), reviews and short communications about applications of materials for biomedical use. JFB covers subjects from chemistry, pharmacy, biology, physics over to engineering. The journal focuses on the preparation, performance and use of functional biomaterials in biomedical devices and their behaviour in physiological environments. Our aim is to encourage scientists to publish their results in as much detail as possible. Therefore, there is no restriction on the length of the papers. The full experimental details must be provided so that the results can be reproduced. Several topical special issues will be published. Scope: adhesion, adsorption, biocompatibility, biohybrid materials, bio-inert materials, biomaterials, biomedical devices, biomimetic materials, bone repair, cardiovascular devices, ceramics, composite materials, dental implants, dental materials, drug delivery systems, functional biopolymers, glasses, hyper branched polymers, molecularly imprinted polymers (MIPs), nanomedicine, nanoparticles, nanotechnology, natural materials, self-assembly smart materials, stimuli responsive materials, surface modification, tissue devices, tissue engineering, tissue-derived materials, urological devices.