An underestimated pathogen: Corynebacterium species.

IF 5.4 2区 医学 Q1 MICROBIOLOGY
Brooks I Mitchell, John E Markantonis
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引用次数: 0

Abstract

Corynebacterium species are a diverse group of organisms historically considered to be non-pathogenic, outside of the C. diphtheriae complex. Over the last few decades, this belief has been disproven with many notable non-diphtheriae Corynebacterium species being found to be pathogenic, often in certain clinical scenarios and/or anatomical sites. C. striatum and C. jeikeium are responsible for a large portion of bloodstream infections and orthopedic infections related to coryneform Gram-positive rods (GPRs). Eye and ear infections have commonly been attributed to C. macginleyi and C. otitidis, respectively. Pneumonia in critically ill and immunosuppressed individuals has been frequently reported by the C. propinquum/pseudodiphtheriticum group and occasionally in C. striatum. C. urealyticum is the primary pathogen associated with encrusted cystitis. Granulomatous lobular mastitis and breast abscesses have a strong association with C. kroppenstedtii. Erythrasma (C. aurimucosum/minutissimum group), trichobacteriosis (C. flavescens), and hidradenitis suppurativa are cutaneous disorders caused by or associated with Corynebacterium species. Biofilm formation by these bacteria leads to hardware/medical device-associated infections involving endovascular catheters, cerebrospinal fluid shunts, peritoneal dialysis catheters, and prosthetic joints. Clinical microbiology laboratories must be aware of this and optimize laboratory identification and reporting of these organisms when appropriate. Matrix-associated laser/adsorption ionization time-of-flight mass spectrometry, currently available in most large clinical microbiology laboratories, offers laboratories the ability to rapidly, accurately, and affordably accomplish this task.

一种被低估的病原体:棒状杆菌。
棒状杆菌是历史上被认为是非致病性的生物,在白喉杆菌复合体之外。在过去的几十年里,这种观点已经被证明是错误的,许多值得注意的非白喉棒状杆菌物种被发现是致病的,通常在某些临床情况和/或解剖部位。纹状体C.和jeikeium C.是大部分与棒状革兰氏阳性棒(GPRs)相关的血流感染和骨科感染的原因。眼睛和耳朵感染通常分别归因于C. macginleyi和C. otititis。在危重病人和免疫抑制的个体中,肺炎经常被丙品c /假性白喉组报道,偶尔在纹状体c中报道。解脲支原体是与结壳性膀胱炎相关的主要病原体。肉芽肿性小叶性乳腺炎和乳腺脓肿与克氏梭菌密切相关。红斑(C. aurimucosum/minutissimum组)、毛杆菌病(C. flavescens)和化脓性汗腺炎是由棒状杆菌引起或与之相关的皮肤病。这些细菌形成的生物膜导致硬件/医疗器械相关感染,包括血管内导管、脑脊液分流管、腹膜透析导管和假体关节。临床微生物实验室必须意识到这一点,并在适当的时候优化这些微生物的实验室鉴定和报告。基质相关激光/吸附电离飞行时间质谱法目前可用于大多数大型临床微生物实验室,为实验室提供快速、准确和经济地完成这项任务的能力。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Journal of Clinical Microbiology
Journal of Clinical Microbiology 医学-微生物学
CiteScore
17.10
自引率
4.30%
发文量
347
审稿时长
3 months
期刊介绍: The Journal of Clinical Microbiology® disseminates the latest research concerning the laboratory diagnosis of human and animal infections, along with the laboratory's role in epidemiology and the management of infectious diseases.
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