Regional 4D Cardiac Magnetic Resonance Strain Predicts Cardiomyopathy Progression in Duchenne Muscular Dystrophy.

IF 6.1 1区 医学 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS
Conner C Earl, Alexa M Jauregui, Marco A Prado, Guang Lin, Kan N Hor, Larry W Markham, Jonathan H Soslow, Craig J Goergen
{"title":"Regional 4D Cardiac Magnetic Resonance Strain Predicts Cardiomyopathy Progression in Duchenne Muscular Dystrophy.","authors":"Conner C Earl, Alexa M Jauregui, Marco A Prado, Guang Lin, Kan N Hor, Larry W Markham, Jonathan H Soslow, Craig J Goergen","doi":"10.1016/j.jocmr.2025.101950","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Cardiomyopathy (CMP) is the leading cause of death in Duchenne muscular dystrophy (DMD). Characterization of disease trajectory can be challenging, especially in early stages of CMP where onset and progression may vary. Traditional metrics from cardiovascular magnetic resonance (CMR) imaging such as LVEF (left ventricular ejection fraction) and LGE (late gadolinium enhancement) are often insufficient for assessing the pace of disease progression. We hypothesized that strain patterns from a novel 4D (3D+time) CMR regional strain analysis method can be used to predict DMD CMP progression.</p><p><strong>Methods: </strong>We compiled 190 short-axis cine CMR image stacks for n=66 pediatric DMD patients (13.3 [10.8-16.5] years; median [interquartile range]) imaged for 3 consecutive years and computed regional strain metrics using custom-built feature tracking software. We measured regional strain parameters from the generated 4D endocardial surface mesh.</p><p><strong>Results: </strong>Using LVEF decrease, measured two years following the initial scan, we classified patients into slow (ΔLVEF%<5; n=35) or fast (ΔLVEF%≥5; n=30) progressing groups. There was no statistical difference between the slow and fast-progressing groups in terms of standard metrics such as age, LVEF, or LGE status. However, peak basal circumferential strain (E<sub>cc</sub>) and surface area strain (E<sub>a</sub>) magnitudes were decreased in fast progressors (p<0.01 for all). Basal E<sub>cc</sub> late diastolic strain rate and basal E<sub>a</sub> late diastolic strain rate magnitude were also significantly decreased in fast progressors (p<0.01 for all).</p><p><strong>Conclusion: </strong>Regional strain metrics from 4D CMR can be used to differentiate between slow or fast CMP progression in a longitudinal DMD cohort.</p>","PeriodicalId":15221,"journal":{"name":"Journal of Cardiovascular Magnetic Resonance","volume":" ","pages":"101950"},"PeriodicalIF":6.1000,"publicationDate":"2025-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Cardiovascular Magnetic Resonance","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1016/j.jocmr.2025.101950","RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CARDIAC & CARDIOVASCULAR SYSTEMS","Score":null,"Total":0}
引用次数: 0

Abstract

Background: Cardiomyopathy (CMP) is the leading cause of death in Duchenne muscular dystrophy (DMD). Characterization of disease trajectory can be challenging, especially in early stages of CMP where onset and progression may vary. Traditional metrics from cardiovascular magnetic resonance (CMR) imaging such as LVEF (left ventricular ejection fraction) and LGE (late gadolinium enhancement) are often insufficient for assessing the pace of disease progression. We hypothesized that strain patterns from a novel 4D (3D+time) CMR regional strain analysis method can be used to predict DMD CMP progression.

Methods: We compiled 190 short-axis cine CMR image stacks for n=66 pediatric DMD patients (13.3 [10.8-16.5] years; median [interquartile range]) imaged for 3 consecutive years and computed regional strain metrics using custom-built feature tracking software. We measured regional strain parameters from the generated 4D endocardial surface mesh.

Results: Using LVEF decrease, measured two years following the initial scan, we classified patients into slow (ΔLVEF%<5; n=35) or fast (ΔLVEF%≥5; n=30) progressing groups. There was no statistical difference between the slow and fast-progressing groups in terms of standard metrics such as age, LVEF, or LGE status. However, peak basal circumferential strain (Ecc) and surface area strain (Ea) magnitudes were decreased in fast progressors (p<0.01 for all). Basal Ecc late diastolic strain rate and basal Ea late diastolic strain rate magnitude were also significantly decreased in fast progressors (p<0.01 for all).

Conclusion: Regional strain metrics from 4D CMR can be used to differentiate between slow or fast CMP progression in a longitudinal DMD cohort.

区域4D心脏磁共振应变预测杜氏肌营养不良患者心肌病进展。
背景:心肌病(CMP)是杜氏肌营养不良症(DMD)患者死亡的主要原因。疾病轨迹的表征可能具有挑战性,特别是在CMP的早期阶段,发病和进展可能各不相同。心血管磁共振(CMR)成像的传统指标,如LVEF(左心室射血分数)和LGE(晚期钆增强)通常不足以评估疾病进展的速度。我们假设一种新的4D (3D+时间)CMR区域应变分析方法的应变模式可用于预测DMD CMP的进展。方法:对n=66例儿童DMD患者(13.3[10.8-16.5]岁;中位数[四分位数间距])连续3年进行190幅短轴CMR影像叠加,并使用定制的特征跟踪软件计算区域应变指标。我们从生成的4D心内膜表面网格中测量区域应变参数。结果:使用初始扫描后两年测量的LVEF下降,我们将患者分为慢速(ΔLVEF%cc)和表面积应变(Ea)大小在快速进展者中降低(pcc舒张晚期应变率和基础Ea舒张晚期应变率大小在快速进展者中也显着降低)。结论:4D CMR的区域应变指标可用于区分纵向DMD队列中CMP缓慢或快速进展。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
CiteScore
10.90
自引率
12.50%
发文量
61
审稿时长
6-12 weeks
期刊介绍: Journal of Cardiovascular Magnetic Resonance (JCMR) publishes high-quality articles on all aspects of basic, translational and clinical research on the design, development, manufacture, and evaluation of cardiovascular magnetic resonance (CMR) methods applied to the cardiovascular system. Topical areas include, but are not limited to: New applications of magnetic resonance to improve the diagnostic strategies, risk stratification, characterization and management of diseases affecting the cardiovascular system. New methods to enhance or accelerate image acquisition and data analysis. Results of multicenter, or larger single-center studies that provide insight into the utility of CMR. Basic biological perceptions derived by CMR methods.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:604180095
Book学术官方微信