Conner C Earl, Alexa M Jauregui, Marco A Prado, Guang Lin, Kan N Hor, Larry W Markham, Jonathan H Soslow, Craig J Goergen
{"title":"Regional 4D Cardiac Magnetic Resonance Strain Predicts Cardiomyopathy Progression in Duchenne Muscular Dystrophy.","authors":"Conner C Earl, Alexa M Jauregui, Marco A Prado, Guang Lin, Kan N Hor, Larry W Markham, Jonathan H Soslow, Craig J Goergen","doi":"10.1016/j.jocmr.2025.101950","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Cardiomyopathy (CMP) is the leading cause of death in Duchenne muscular dystrophy (DMD). Characterization of disease trajectory can be challenging, especially in early stages of CMP where onset and progression may vary. Traditional metrics from cardiovascular magnetic resonance (CMR) imaging such as LVEF (left ventricular ejection fraction) and LGE (late gadolinium enhancement) are often insufficient for assessing the pace of disease progression. We hypothesized that strain patterns from a novel 4D (3D+time) CMR regional strain analysis method can be used to predict DMD CMP progression.</p><p><strong>Methods: </strong>We compiled 190 short-axis cine CMR image stacks for n=66 pediatric DMD patients (13.3 [10.8-16.5] years; median [interquartile range]) imaged for 3 consecutive years and computed regional strain metrics using custom-built feature tracking software. We measured regional strain parameters from the generated 4D endocardial surface mesh.</p><p><strong>Results: </strong>Using LVEF decrease, measured two years following the initial scan, we classified patients into slow (ΔLVEF%<5; n=35) or fast (ΔLVEF%≥5; n=30) progressing groups. There was no statistical difference between the slow and fast-progressing groups in terms of standard metrics such as age, LVEF, or LGE status. However, peak basal circumferential strain (E<sub>cc</sub>) and surface area strain (E<sub>a</sub>) magnitudes were decreased in fast progressors (p<0.01 for all). Basal E<sub>cc</sub> late diastolic strain rate and basal E<sub>a</sub> late diastolic strain rate magnitude were also significantly decreased in fast progressors (p<0.01 for all).</p><p><strong>Conclusion: </strong>Regional strain metrics from 4D CMR can be used to differentiate between slow or fast CMP progression in a longitudinal DMD cohort.</p>","PeriodicalId":15221,"journal":{"name":"Journal of Cardiovascular Magnetic Resonance","volume":" ","pages":"101950"},"PeriodicalIF":6.1000,"publicationDate":"2025-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Cardiovascular Magnetic Resonance","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1016/j.jocmr.2025.101950","RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CARDIAC & CARDIOVASCULAR SYSTEMS","Score":null,"Total":0}
引用次数: 0
Abstract
Background: Cardiomyopathy (CMP) is the leading cause of death in Duchenne muscular dystrophy (DMD). Characterization of disease trajectory can be challenging, especially in early stages of CMP where onset and progression may vary. Traditional metrics from cardiovascular magnetic resonance (CMR) imaging such as LVEF (left ventricular ejection fraction) and LGE (late gadolinium enhancement) are often insufficient for assessing the pace of disease progression. We hypothesized that strain patterns from a novel 4D (3D+time) CMR regional strain analysis method can be used to predict DMD CMP progression.
Methods: We compiled 190 short-axis cine CMR image stacks for n=66 pediatric DMD patients (13.3 [10.8-16.5] years; median [interquartile range]) imaged for 3 consecutive years and computed regional strain metrics using custom-built feature tracking software. We measured regional strain parameters from the generated 4D endocardial surface mesh.
Results: Using LVEF decrease, measured two years following the initial scan, we classified patients into slow (ΔLVEF%<5; n=35) or fast (ΔLVEF%≥5; n=30) progressing groups. There was no statistical difference between the slow and fast-progressing groups in terms of standard metrics such as age, LVEF, or LGE status. However, peak basal circumferential strain (Ecc) and surface area strain (Ea) magnitudes were decreased in fast progressors (p<0.01 for all). Basal Ecc late diastolic strain rate and basal Ea late diastolic strain rate magnitude were also significantly decreased in fast progressors (p<0.01 for all).
Conclusion: Regional strain metrics from 4D CMR can be used to differentiate between slow or fast CMP progression in a longitudinal DMD cohort.
期刊介绍:
Journal of Cardiovascular Magnetic Resonance (JCMR) publishes high-quality articles on all aspects of basic, translational and clinical research on the design, development, manufacture, and evaluation of cardiovascular magnetic resonance (CMR) methods applied to the cardiovascular system. Topical areas include, but are not limited to:
New applications of magnetic resonance to improve the diagnostic strategies, risk stratification, characterization and management of diseases affecting the cardiovascular system.
New methods to enhance or accelerate image acquisition and data analysis.
Results of multicenter, or larger single-center studies that provide insight into the utility of CMR.
Basic biological perceptions derived by CMR methods.