Multi-centre Investigation of Cardiac Diffusion Tensor Imaging in Healthy Volunteers by SCMR Cardiac Diffusion Special Interest Group NETwork (SIGNET).

IF 6.1 1区 医学 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS
Irvin Teh, Kévin Moulin, Pedro F Ferreira, Julie Absil, Maryam Afzali, Peter Agger, Behnaz Akbari, Anthony H Aletras, Satoru Aono, Charles Benton, Suryava Bhattacharya, Pierre Croisille, Yves De Bruecker, Erica Dall'Armellina, Daniel B Ennis, Carl Glessgen, Anna Glinska, Sandra Haltmeier, Ariel Hannum, Erik Hedström, Tawfik Hussein, Sarah Jones, George Joy, Karen Kettless, Won Yong Kim, Sebastian Kozerke, Julie Magat, Raja Muthupillai, Reza Nezafat, Sonia Nielles-Vallespin, John Oshinski, Valéry Ozenne, Dudley J Pennell, Roderick Pettigrew, Iain Pierce, Betty Raman, Agnieszka Sabisz, Jürgen E Schneider, Janet H Sherman, Abhishek Shetye, Rolf Symons, Philippe Thoma, Thomas Treibel, Satonori Tsuneta, Jean-Paul Vallee, Niels Vejlstrup, Magalie Viallon, Christopher Nguyen, Andrew D Scott, Christian T Stoeck
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引用次数: 0

Abstract

Background: Cardiac diffusion tensor imaging (cDTI) is an emerging technique for microstructural characterization of the heart and has shown clinical potential in a range of cardiomyopathies. However, there is substantial variation reported for in vivo cDTI results across the literature, and sensitivity of cDTI to differences in imaging sites, scanners, acquisition protocols and post-processing methods remains incompletely understood.

Methods: SIGNET is a prospective multi-centre, observational study in travelling and non-travelling healthy volunteers. The study was initiated by the executive board of the SCMR Cardiac Diffusion Special Interest Group (SIG) as a follow up to a previous multi-centre study on phantom validation of cardiac DTI and a recently published SCMR consensus statement on cardiac diffusion MRI. The study has been developed by the Project Management Committee in consultation with the SCMR Cardiac Diffusion SIG, which includes international experts in cardiac diffusion MRI. To date, more than 20 international institutions have engaged with the study, including sites that are new to cardiac DTI, making this the largest collaborative effort in the field.

Discussion: SIGNET will provide important information about the key sources of variation in cardiac DTI. This will help rationalise strategies for addressing and minimising such variation. Harmonisation of protocols in this and future studies will underpin efforts to translate cardiac DTI for clinical application.

SCMR心脏弥散特别兴趣组网络(SIGNET)对健康志愿者心脏弥散张量成像的多中心研究。
背景:心脏弥散张量成像(cDTI)是一种用于心脏微结构表征的新兴技术,在一系列心肌病中显示出临床潜力。然而,文献中报道的体内cDTI结果存在很大差异,cDTI对成像部位、扫描仪、采集方案和后处理方法差异的敏感性仍不完全清楚。方法:SIGNET是一项前瞻性多中心观察性研究,研究对象为旅行和非旅行的健康志愿者。这项研究是由SCMR心脏弥散特别兴趣小组(SIG)执行委员会发起的,作为先前关于心脏DTI幻像验证的多中心研究和最近发表的SCMR关于心脏弥散MRI共识声明的后续研究。这项研究是由项目管理委员会与SCMR心脏扩散小组协商后制定的,该小组包括心脏扩散MRI的国际专家。迄今为止,已有20多个国际机构参与了这项研究,包括心脏DTI的新站点,使其成为该领域最大的合作努力。讨论:SIGNET将提供关于心脏DTI变异的关键来源的重要信息。这将有助于使解决和尽量减少这种变化的战略合理化。在这个和未来的研究方案的协调将巩固努力转化心脏DTI临床应用。
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来源期刊
CiteScore
10.90
自引率
12.50%
发文量
61
审稿时长
6-12 weeks
期刊介绍: Journal of Cardiovascular Magnetic Resonance (JCMR) publishes high-quality articles on all aspects of basic, translational and clinical research on the design, development, manufacture, and evaluation of cardiovascular magnetic resonance (CMR) methods applied to the cardiovascular system. Topical areas include, but are not limited to: New applications of magnetic resonance to improve the diagnostic strategies, risk stratification, characterization and management of diseases affecting the cardiovascular system. New methods to enhance or accelerate image acquisition and data analysis. Results of multicenter, or larger single-center studies that provide insight into the utility of CMR. Basic biological perceptions derived by CMR methods.
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