{"title":"Desmoid-Type Fibromatosis Masquerading as Disease Progression in Metastatic Breast Cancer in a Patient on Ribociclib Therapy: A Case Report.","authors":"Ha Rim Ahn, Ae Ri Ahn, Hyun Jo Youn","doi":"10.4048/jbc.2025.0107","DOIUrl":null,"url":null,"abstract":"<p><p>Ribociclib combined with an aromatase inhibitor (AI) is widely used as first-line therapy for hormone receptor (HR)-positive, human epidermal growth factor receptor-2 (HER-2)-negative metastatic breast cancer. Desmoid-type fibromatosis (DTF) is a rare, locally invasive soft-tissue tumor that accounts for only 0.2% of all breast neoplasms and can mimic malignancy upon imaging. A 44-year-old premenopausal woman with HR-positive, HER2-negative bone-only metastatic breast cancer developed a rapidly growing breast mass after 30 cycles of ribociclib with an AI. Imaging suggested cancer progression, necessitating total mastectomy. However, postoperative pathology confirmed DTF, which is a rare occurrence that has not been previously reported. Appropriate therapeutic planning and follow-up for metastatic breast cancer should include histopathological diagnosis, when necessary, beyond clinical and imaging assessments.</p>","PeriodicalId":15206,"journal":{"name":"Journal of Breast Cancer","volume":"28 4","pages":"288-294"},"PeriodicalIF":2.4000,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12411080/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Breast Cancer","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.4048/jbc.2025.0107","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"ONCOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Ribociclib combined with an aromatase inhibitor (AI) is widely used as first-line therapy for hormone receptor (HR)-positive, human epidermal growth factor receptor-2 (HER-2)-negative metastatic breast cancer. Desmoid-type fibromatosis (DTF) is a rare, locally invasive soft-tissue tumor that accounts for only 0.2% of all breast neoplasms and can mimic malignancy upon imaging. A 44-year-old premenopausal woman with HR-positive, HER2-negative bone-only metastatic breast cancer developed a rapidly growing breast mass after 30 cycles of ribociclib with an AI. Imaging suggested cancer progression, necessitating total mastectomy. However, postoperative pathology confirmed DTF, which is a rare occurrence that has not been previously reported. Appropriate therapeutic planning and follow-up for metastatic breast cancer should include histopathological diagnosis, when necessary, beyond clinical and imaging assessments.
期刊介绍：
The Journal of Breast Cancer (abbreviated as ''J Breast Cancer'') is the official journal of the Korean Breast Cancer Society, which is issued quarterly in the last day of March, June, September, and December each year since 1998. All the contents of the Journal is available online at the official journal website (http://ejbc.kr) under open access policy. The journal aims to provide a forum for the academic communication between medical doctors, basic science researchers, and health care professionals to be interested in breast cancer. To get this aim, we publish original investigations, review articles, brief communications including case reports, editorial opinions on the topics of importance to breast cancer, and welcome new research findings and epidemiological studies, especially when they contain a regional data to grab the international reader''s interest. Although the journal is mainly dealing with the issues of breast cancer, rare cases among benign breast diseases or evidence-based scientifically written articles providing useful information for clinical practice can be published as well.
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