Vascular function in women with heart failure with preserved ejection fraction: a mismatch beyond diastole.

IF 3.3 3区医学 Q1 PHYSIOLOGY

Journal of applied physiology Pub Date : 2025-09-01 Epub Date: 2025-08-21 DOI:10.1152/japplphysiol.00467.2025

Nicholas A Carlini, D Walter Wray, Kerrie L Moreau, Kanokwan Bunsawat

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引用次数: 0

Abstract

Heart failure with preserved ejection fraction (HFpEF) is a complex multiorgan clinical syndrome representing ∼50% of all heart failure-related cases nationwide. HFpEF is more prevalent in women, yet both men and women with HFpEF present with distinct clinical phenotypes and prognosis that may be attributable, in part, to sex differences in anatomical, physiological, and/or hormonal characteristics. Of particular interest is the role of sex hormones, namely, estrogen, as a contributing factor to sex differences in vascular health in patients with HFpEF. This mini review provides a summary of recent evidence regarding sex differences in coronary microvascular function, peripheral vascular function, and central arterial stiffness in patients with HFpEF. Focus will also be given to potential mechanisms by which age-related loss of estrogen may alter these aspects of physiology in women with HFpEF and provide potential future directions related to implications for women's health in adults with HFpEF.

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保留射血分数的心力衰竭女性的血管功能：舒张期以外的不匹配。

保射血分数心力衰竭是一种复杂的多器官临床综合征，约占全国心力衰竭相关病例的50%。HFpEF在女性中更为普遍，但患有HFpEF的男性和女性都有不同的临床表型和预后，这可能部分归因于解剖、生理和/或激素特征的性别差异。特别令人感兴趣的是性激素，即雌激素，作为HFpEF患者血管健康性别差异的促成因素的作用。这篇小型综述总结了关于HFpEF患者冠状动脉微血管功能、外周血管功能和中心动脉硬度的性别差异的最新证据。重点还将放在与年龄相关的雌激素丧失可能改变HFpEF妇女这些生理方面的潜在机制上，并提供与成年HFpEF妇女健康影响相关的潜在未来方向。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of applied physiology 医学-生理学

CiteScore

6.00

自引率

9.10%

发文量

296

审稿时长

2-4 weeks

期刊介绍： The Journal of Applied Physiology publishes the highest quality original research and reviews that examine novel adaptive and integrative physiological mechanisms in humans and animals that advance the field. The journal encourages the submission of manuscripts that examine the acute and adaptive responses of various organs, tissues, cells and/or molecular pathways to environmental, physiological and/or pathophysiological stressors. As an applied physiology journal, topics of interest are not limited to a particular organ system. The journal, therefore, considers a wide array of integrative and translational research topics examining the mechanisms involved in disease processes and mitigation strategies, as well as the promotion of health and well-being throughout the lifespan. Priority is given to manuscripts that provide mechanistic insight deemed to exert an impact on the field.