Leveraging Functional and Structural Connectomics to Guide Neuromodulation in Epilepsy.

IF 1.7 4区 医学 Q3 CLINICAL NEUROLOGY
Ketan Mehta, Arianna Damiani, Elvira Pirondini, Shruti Agashe, Cameron C McIntyre, Jorge A Gonzalez-Martinez
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引用次数: 0

Abstract

Summary: Epilepsy is not solely a disorder of abnormal brain structure; it is fundamentally a disorder of disrupted brain networks and impaired communication across brain regions. Thalamic neuromodulation, once conceptualized as a fixed, anatomically guided intervention, is now undergoing a paradigm shift toward dynamic, network-informed modulation. Using tools such as stereo-EEG, diffusion MRI, and advanced connectomic analyses, we are entering a new era where neurostimulation strategies can be individualized, responsive, and aligned with the real-time neurophysiology and structural networks of each patient. By integrating anatomic and functional connectivity data, we are moving toward precision neuromodulation tailored to patient-specific seizure networks. In this review, we highlight the emerging role of functional and structural connectivity in refining our understanding of seizure dynamics and guiding neuromodulation interventions.

利用功能和结构连接组学指导癫痫的神经调节。
总结:癫痫不仅仅是一种大脑结构异常的疾病;从根本上说,它是一种大脑网络紊乱和大脑区域间沟通受损的疾病。丘脑神经调节,曾经被定义为一种固定的、解剖学指导的干预,现在正经历着向动态的、网络知情的调节的范式转变。利用立体脑电图、弥散MRI和先进的连接组分析等工具,我们正在进入一个新的时代,在这个时代,神经刺激策略可以个性化、反应迅速,并与每个患者的实时神经生理学和结构网络保持一致。通过整合解剖和功能连接数据,我们正在朝着精确的神经调节方向发展,为患者特定的癫痫发作网络量身定制。在这篇综述中,我们强调了功能和结构连接在完善我们对癫痫发作动力学的理解和指导神经调节干预方面的新兴作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Journal of Clinical Neurophysiology
Journal of Clinical Neurophysiology 医学-临床神经学
CiteScore
4.60
自引率
4.20%
发文量
198
审稿时长
6-12 weeks
期刊介绍: ​The Journal of Clinical Neurophysiology features both topical reviews and original research in both central and peripheral neurophysiology, as related to patient evaluation and treatment. Official Journal of the American Clinical Neurophysiology Society.
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